Clinical trial · Interventional
Surgical Glove Compression to Prevent Paclitaxel Neuropathy
Comparison of Surgical Glove Compressions as a Prophylactic Method to Prevent Paclitaxel-induced Peripheral Neuropathy: Randomized Controlled Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study aims to evaluate the effect of surgical glove compression as a prophylactic method to prevent paclitaxel-induced peripheral neuropathy. Participants will be randomly assigned to two groups: one receiving standard care, and the other receiving prophylactic surgical glove compression. The study will compare the development, severity of neuropathy in the hands and fingers, and its impact on quality of life.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Paclitaxel-Induced Peripheral Neuropathy | — | UNRESOLVED | — |
| Surgical Glove | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Surgical glove compression during paclitaxel infusion | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- OTHER
- label
- Intervention Group 1
- description
- A standard surgical glove (½ size smaller) will be worn on the same hand 30 minutes before, during, and 30 minutes after paclitaxel infusion. Glove size will be determined by the study nurse based on hand measurements.
- interventionNames
- Other: Surgical glove compression during paclitaxel infusion
- type
- OTHER
- label
- Intervention Group 2
- description
- Two standard surgical gloves will be worn on the same hand: first ½ size smaller, second 1 size smaller. Gloves will be worn 30 minutes before, during, and 30 minutes after paclitaxel infusion. Glove sizes determined by study nurse.
- interventionNames
- Other: Surgical glove compression during paclitaxel infusion
- type
- OTHER
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Patients aged between 18 and 80 years * Diagnosed with Stage II-III breast cancer * No distant metastasis * Planned to receive adjuvant or neoadjuvant paclitaxel for at least 12 weeks * Willing and able to provide informed consent * Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2 Karnofsky ≥ 60%) Exclusion Criteria: * Recurrent breast cancer * Prior treatment associated with neuropathy (e.g., taxanes, platinum-based chemotherapy, anti-tubulin or proteasome inhibitors)
References
Publications (0)
Data not yet available