Clinical trial · Interventional
Evidence-Based Nursing Plus Progressive Exercise for Cancer-Related Fatigue in Advanced Lung Cancer
Effect of Evidence-Based Nursing Combined With Progressive Gymnastics Training on Cancer-Related Fatigue, Quality of Life, and Treatment Adherence in Patients With Advanced Lung Cancer Undergoing Chemotherapy: A Randomized Controlled Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study aims to evaluate the effectiveness and safety of evidence-based nursing combined with progressive exercise training in patients with advanced lung cancer undergoing chemotherapy. Cancer-related fatigue (CRF) is a common and distressing symptom in this population and is associated with poor quality of life and reduced treatment adherence. In this single-center, prospective randomized controlled trial, 100 patients with stage III-IV lung cancer receiving platinum-based chemotherapy were randomly assigned to either a control group or an intervention group. The control group received routine nursing care, while the intervention group received evidence-based nursing combined with a structured progressive exercise program for 8 weeks. The primary outcomes are cancer-related fatigue assessed by the Brief Fatigue Inventory (BFI) and functional exercise capacity assessed by the 6-minute walk test (6MWT). Secondary outcomes include quality of life (EORTC QLQ-C30), treatment adherence (MMAS-8), psychological status (HADS), sleep quality (PSQI), and safety outcomes. The study is designed to determine whether a combined intervention approach integrating nursing care and exercise rehabilitation can provide greater benefits than routine care alone in improving both physical and psychological outcomes in patients with advanced lung cancer.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Advanced Lung Cancer | Malignant Lung Neoplasm | CURATED_BROADER | 0.78 |
| Cancer-related Fatigue | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Evidence-Based Nursing | Behavioral | — | UNRESOLVED |
| Progressive Exercise Training | Behavioral | — | UNRESOLVED |
| Routine Nursing Care | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Intervention Group: Evidence-Based Nursing Plus Progressive Exercise
- description
- Participants in the intervention group received routine nursing care combined with evidence-based nursing and a structured progressive exercise training program for 8 weeks. Evidence-based nursing included individualized health education, psychological support, symptom management, and family involvement based on current best evidence. The exercise program consisted of aerobic and resistance training with gradually increasing intensity, tailored to each patient's physical condition and tolerance, and supervised by rehabilitation specialists and nursing staff.
- interventionNames
- Behavioral: Evidence-Based Nursing
- Behavioral: Progressive Exercise Training
- Other: Routine Nursing Care
- type
- ACTIVE_COMPARATOR
- label
- Control Group: Routine Nursing Care
- description
- Participants in the control group received routine nursing care, including standard health education, dietary guidance, symptom monitoring, and general psychological support. No structured exercise rehabilitation program or evidence-based nursing protocol was provided.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Pathologically confirmed advanced lung cancer (stage III-IV) * Currently receiving platinum-based chemotherapy (first to fourth cycle) * Age ≥18 years * Karnofsky Performance Status (KPS) score ≥60 * Presence of moderate or more severe cancer-related fatigue, defined as a Brief Fatigue Inventory (BFI) score ≥4 * Expected survival time of more than 6 months * Ability to understand the study procedures and provide written informed consent Exclusion Criteria: * Severe cardiopulmonary insufficiency or other conditions that contraindicate exercise intervention * Cognitive impairment or mental disorders affecting compliance with the intervention * Musculoskeletal disorders that limit physical activity or exercise participation * Presence of other advanced malignant tumors * Rapid disease progression during the study period requiring discontinuation of the intervention
References
Publications (0)
Data not yet available