Clinical trial · Interventional
Ischemic Preconditioning Reduces the Severity of Acute Kidney Injury After Partial Nephrectomy
Ischemic Preconditioning Reduces the Severity of Acute Kidney Injury After Partial Nephrectomy: a Randomized Controlled Clinical Study
NCT07497958CI-TRIAL-00106545not yet recruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
It is demonstrated that remote ischemic preconditioning can alleviate the degree of acute renal injury on the operated side in patients undergoing partial nephrectomy.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Renal Cell Carcinoma (RCC) | Renal Cell Carcinoma | CURATED_BROADER | 0.80 |
| Renal Function Abnormal | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Ischemic preconditioning | Procedure | — | UNRESOLVED |
| NO ischemic preconditioning | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Experimental : Ischemic preconditioning
- description
- One day before the surgery, use a sphygmomanometer to apply pressure to the patient's upper limb to 200mmHg for 5 minutes, then reduce the pressure to 0mmHg for 5 minutes, repeating this process for a total of 3 cycles. On the second day, perform a routine partial nephrectomy
- interventionNames
- Procedure: Ischemic preconditioning
- type
- ACTIVE_COMPARATOR
- label
- Comparator : No ischemic preconditioning
- description
- Routine partial nephrectomy
- interventionNames
- Procedure: NO ischemic preconditioning
Primary outcomes (1)
- measure
- AIRD spectrum score based on the patient's preoperative creatinine level and postoperative peak creatinine level
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Patients who are scheduled to undergo partial nephrectomy, with no specific surgical procedure limitation, including laparoscopic surgery, robot-assisted surgery, and open surgery * Aged 18 to 80 * Possess good organ function status: sufficient organ function (based on the normal values of the clinical trial center) 1. Blood routine test: WBC≥3.5×10\^9/L, absolute neutrophil count ≥1.5×10\^9/L, PLT≥75.0×10\^9/L, HGB≥80g/L; 2. Liver function: Total bilirubin ≤1.5×upper limit of normal (ULN), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤2.5×ULN; Exclusion Criteria: * The anesthesiologist assesses that the patient cannot tolerate general anesthesia surgery * Individuals with severe cardiovascular and cerebrovascular diseases, uncontrolled hypertension, and diabetes * Estimated glomerular filtration rate (eGFR) \< 30 ml/min/1.73m² * Horseshoe kidney * Solitary kidney * Pregnant women
References
Publications (0)
Data not yet available
No reference posted for this study.