Clinical trial · Observational
G8 Screening Tool Validation in Older Adults With Cancer in Portugal
Prospective Validation of the G8 Geriatric Screening Tool in Older Adults With Cancer in Portugal (G8-PT Study)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The G8 screening tool is widely recommended for the identification of frailty in older adults with cancer. However, prospective validation data in the Portuguese population are currently lacking. This prospective observational study aims to evaluate the diagnostic performance of the G8 screening tool compared with a Comprehensive Geriatric Assessment (CGA) in older adults with cancer. Patients aged ≥70 years with solid tumors will be assessed using both the G8 screening tool and a multidimensional CGA. Frailty will be defined as impairment in at least one CGA domain. The performance of the G8 will be evaluated in terms of sensitivity, specificity, and area under the receiver operating characteristic curve. This study aims to provide the first prospective validation of the G8 screening tool in Portuguese older adults with cancer and to support its implementation in clinical practice.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Aged | — | UNRESOLVED | — |
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Frailty | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Comprehensive Geriatric Assessment | Other | — | UNRESOLVED |
| G8 Screening Tool | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Older Adults With Cancer
- description
- Patients aged ≥70 years with a diagnosis of cancer undergoing geriatric assessment, including G8 screening and comprehensive geriatric assessment.
- interventionNames
- Other: G8 Screening Tool
- Other: Comprehensive Geriatric Assessment
Primary outcomes (1)
- measure
- Diagnostic Accuracy of the G8 Screening Tool for Detecting Frailty
- timeFrame
- At baseline (single assessment at study inclusion)
- description
- The diagnostic performance of the G8 screening tool will be evaluated against comprehensive geriatric assessment (CGA) as the reference standard. Measures will include sensitivity, specificity, positive predictive value, and negative predictive value for identifying frailty.
Secondary outcomes (3)
- measure
- Prevalence of Frailty Based on Comprehensive Geriatric Assessment
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * Age ≥70 years; * Histologically confirmed solid malignancy, regardless of tumor site or stage; * Referral to a multidisciplinary geriatric oncology consultation; * Consideration for or planned systemic anticancer treatment; * Ability to understand and respond to assessment tools (G8 and comprehensive geriatric assessment), with or without caregiver assistance; * Provision of written informed consent by the patient or legal representative. Exclusion Criteria: * Age \<70 years; * Diagnosis of hematological malignancy (e.g., leukemia, lymphoma, multiple myeloma); * Severe cognitive impairment precluding completion of assessment tools without available caregiver support; * Clinical instability or acute condition preventing data collection (e.g., hospitalization for acute complication); * Refusal to participate or inability to provide informed consent.
References
Publications (0)
Data not yet available