Clinical trial · Observational
Molecular Profiling of MRI-PSMA PET Discordance in Prostate Cancer
Molecular Profiling of Prostate Cancer Lesions With MRI-PSMA PET Discordance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
MRI and PSMA-PET are highly sensitive imaging tools for prostate cancer, yet they often detect different lesions. These discordant findings pose clinical uncertainty because their biological significance is unclear. This project aims to molecularly characterize MRI-PSMA PET discordant lesions using high-quality biobanked samples from patients enrolled in an institutional study (NCT06187870). By integrating imaging and molecular data, the study will clarify whether these lesions represent indolent disease, aggressive subclones, or biologically distinct entities, and will assess their clinical implications.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Molecular Imaging | — | UNRESOLVED | — |
| Prostate Cancer | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
| PSMA PET/CT | — | UNRESOLVED | — |
| RNA | — | UNRESOLVED | — |
| Transcriptomics | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (2)
- measure
- Number of omic features in MRI-PSMA PET discordant versus concordant lesions
- timeFrame
- At the time of biopsy
- measure
- Number of molecular features in MRI-PSMA PET discordant versus concordant lesions
- timeFrame
- At the time of biopsy
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Signed informed consent * PCa diagnosis * Available samples * Performed both PSMA PET and MRI Exclusion Criteria: * Low quality samples availability
References
Publications (0)
Data not yet available