Clinical trial · Observational
Effect of CYP2D6*10 Gene Mutation on Perioperative Precision Analgesia of Oxycodone in Elderly Patients
Effect of CYP2D6 on Perioperative Analgesia of Oxycodone in Elderly Patients
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this prospective study was to determine the effect of CYP2D6 gene polymorphism on perioperative analgesia of oxycodone in elderly patients, and to assign the CYP2D6 phenotype according to the genotype, and to use inhibitors for pain control of phenotype conversion. The significance is to accurately guide the perioperative analgesia of oxycodone in elderly patients, and to more effectively avoid toxicity and adverse reactions.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Oxycodone | — | UNRESOLVED | — |
| Pain | — | UNRESOLVED | — |
| Pulmonary Nodules | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| oxycodone | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- label
- PM group
- interventionNames
- Drug: oxycodone
- label
- IM group
- interventionNames
- Drug: oxycodone
- label
- NM group
- interventionNames
- Drug: oxycodone
- label
- UM group
- interventionNames
- Drug: oxycodone
Primary outcomes (1)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 60 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: ( 1 ) Age ≥ 60 years old ; ( 2 ) ASA grade I \~ II ; ( 3 ) Receiving radical resection of lung cancer ; ( 4 ) BMI was 18.5 \~ 29.9 kg / m2 \[ BMI = weight ( Kg ) / height ( m ) 2 \] ( 2013 US ' Adult Overweight and Obesity Management Guidelines ' ). \- Exclusion Criteria: ( 1 ) Patients with severe liver and kidney dysfunction ( severe liver dysfunction : ALT, AST, ALP, total bilirubin, etc. One of them \> 2 times the upper limit of normal value. Severe renal dysfunction : creatinine \> 2 times the upper limit of normal ) ; ( 2 ) Identify / suspect abuse or long-term use of narcotic sedative analgesics ; ( 3 ) Reoperation within 3 months ; ( 4 ) Patients with contraindications or allergies to test drugs and other narcotic drugs ; ( 5 ) CYP2D6 inhibitors or inducers were used within 30 days ; ( 6 ) Have a history of smoking, heavy drinking or drug use. \-
References
Publications (0)
Data not yet available