Clinical trial · Observational
Skin Conductance for Predicting Spinal Anesthesia-Induced Hypotension in Geriatric Urologic Oncology Patients
Skin Conductance as a Predictor of Spinal Anesthesia-Induced Hypotension in Geriatric Oncology Patients
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Spinal anesthesia-induced hypotension is a common and clinically significant complication in elderly patients undergoing oncologic surgery. Early identification of patients at risk for hemodynamic instability remains a major challenge in perioperative management. Skin conductance reflects sympathetic nervous system activity and may provide a noninvasive indicator of autonomic responses. This prospective observational study aims to evaluate whether skin conductance measurements can predict the development of hypotension following spinal anesthesia in geriatric oncology patients undergoing urologic surgery. The findings may contribute to improved perioperative monitoring and early risk stratification in this vulnerable patient population.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Aged | — | UNRESOLVED | — |
| Hypotension | — | UNRESOLVED | — |
| Spinal Anesthesia | — | UNRESOLVED | — |
| Urologic Neoplasms | Urinary Tract Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Skin Conductance Monitoring | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Geriatric Urologic Oncology Patients Undergoing Spinal Anesthesia
- description
- Geriatric patients undergoing urologic oncology surgery under spinal anesthesia will be prospectively observed. Skin conductance will be continuously monitored perioperatively as a noninvasive indicator of sympathetic nervous system activity. Hemodynamic parameters, including blood pressure and heart rate, will be recorded before and after spinal anesthesia. The occurrence of spinal anesthesia-induced hypotension will be assessed and its association with skin conductance measurements will be evaluated.
- interventionNames
- Other: Skin Conductance Monitoring
Primary outcomes (1)
- measure
- Number of Participants with Spinal Anesthesia-Induced Hypotension
- timeFrame
- From initiation of spinal anesthesia until 20 minutes after spinal anesthesia.
- description
- The number of participants who experience hypotension, defined as a decrease in mean arterial pressure (MAP) of ≥20% from baseline or a MAP \<65 mmHg, within 20 minutes after spinal anesthesia. Time Frame: From initiation of spinal anesthesia until 30 minutes after spinal anesthesia.
Secondary outcomes (4)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Patients aged 65 years and older * Patients scheduled for elective urologic oncology surgery under spinal anesthesia * American Society of Anesthesiologists (ASA) physical status I-III * Patients who provide written informed consent to participate in the study Exclusion Criteria: * Refusal to participate or inability to provide informed consent * Contraindication to spinal anesthesia (e.g., infection at puncture site, coagulopathy) * Severe cardiac conduction abnormalities or presence of a cardiac pacemaker * Severe autonomic dysfunction or known neuropathy affecting autonomic responses * Use of medications that significantly affect autonomic nervous system activity * Baseline hypotension or hemodynamic instability before spinal anesthesia * Inability to obtain reliable skin conductance measurements (e.g., severe skin lesions at electrode placement site)
References
Publications (3)
- BACKGROUNDNorbeck DW, Lindgren S, Wolf A, Jildenstal P. Reliability of nociceptive monitors vs. standard practice during general anesthesia: a prospective observational study. BMC Anesthesiol. 2025 Jan 31;25(1):51. doi: 10.1186/s12871-025-02923-4. PMID 39891061
- BACKGROUNDStorm H. Changes in skin conductance as a tool to monitor nociceptive stimulation and pain. Curr Opin Anaesthesiol. 2008 Dec;21(6):796-804. doi: 10.1097/ACO.0b013e3283183fe4. PMID 18997532
- BACKGROUNDLedowski T, Preuss J, Kapila R, Ford A. Skin conductance as a means to predict hypotension following spinal anaesthesia. Acta Anaesthesiol Scand. 2008 Nov;52(10):1342-7. doi: 10.1111/j.1399-6576.2008.01697.x. PMID 19025525