Clinical trial · Interventional
TEAS Combined With Triple Antiemetic Drugs to Prevent PONV in High-Risk Patients
Transcutaneous Electrical Acupoint Stimulation Combined With Triple Antiemetic Drugs for Postoperative Nausea and Vomiting in High-Risk Patients: A Multicenter Randomized Controlled Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this clinical trial is to evaluate the effects of transcutaneous electrical acupoint stimulation (TEAS) combined with triple antiemetics for postoperative nausea and vomiting (PONV) in high-risk patients. The primary question it seeks to answer is: Does TEAS combined with triple antiemetics further reduce the incidence of PONV in high-risk subjects? Researchers will compare active TEAS with sham stimulation to determine whether the addition of TEAS to dexamethasone, palonosetron, and droperidol lowers the PONV rate beyond that achieved by the triple-drug prophylaxis alone.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gallstones | — | UNRESOLVED | — |
| Ovarian Tumors | Ovarian Neoplasm | ALIAS | 0.90 |
| Uterine Fibroids (Leiomyoma) | Uterine Corpus Leiomyoma | ALIAS | 0.85 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Sham transcutaneous electrical acupoint stimulation | Device | — | UNRESOLVED |
| transcutaneous electrical acupoint stimulation | Device | — | UNRESOLVED |
| triple antiemetic drugs | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- The TEAS group
- description
- The TEAS group，Nei-guan (PC6) and He-gu (LI4) were stimulated by a transcutaneous acupoint electrical stimulation instrument approximately 30 minutes before anesthesia induction until the patient is discharged from the operating room.
- interventionNames
- Device: transcutaneous electrical acupoint stimulation
- Drug: triple antiemetic drugs
- type
- SHAM_COMPARATOR
- label
- The control group
- description
- The same protocol was applied for percutaneous acupoint electrical stimulation, initiated before anesthesia induction with the minimum perceptible current (MPC) and terminated after 1 minute. To ensure complete blinding, both groups were covered with opaque sheets over the percutaneous acupoint electrical stimulation device.
- interventionNames
- Device: Sham transcutaneous electrical acupoint stimulation
- Drug: triple antiemetic drugs
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Women scheduled for laparoscopic surgery ； * Aged 18-65 years； * ASA Class I-III； * Apfel score ≥ 3 (female sex, non-smoker, history of PONV and/or motion sickness). Exclusion Criteria: * Patients with a history of allergy to the investigational drug or contraindications； * Long-QT syndrome ； * Pregnancy, lactation, or menstruation ； * Current smoker； * Nausea/vomiting or use of antiemetics, opioids, or systemic corticosteroids within 24 h before surgery； * Requirement for post-operative sedation and mechanical ventilation ； * Severe renal or hepatic impairment ； * Psychiatric or neurological disorder ； * Vertebrobasilar insufficiency； * Vestibular disease； * Language or communication barrier ； * Skin lesion or infection at the acupoint stimulation site ； * Upper-limb nerve injury ； * Implanted cardiac pacemaker or defibrillator ； * Participation in another clinical trial within the past 4 weeks.
References
Publications (0)
Data not yet available