Clinical trial · Observational
A Study on Intratumoral Fibrosis and α-SMA Expression in Intrahepatic Cholangiocarcinoma
MRI-Based Radiomics and Machine Learning for Preoperative Assessment of Intratumoral Fibrosis and α-Smooth Muscle Actin Expression in Intrahepatic Cholangiocarcinoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of this observational study was to understand the prognostic imaging of the degree of intratumoral fibrosis and intratumoral α-SMA levels in patients with intrahepatic cholangiocarcinoma (ICC). The main questions it aims to answer are: Whether the degree of intratumoral fibrosis and the level of intratumoral α-SMA affect the overall survival and progression-free survival of ICC patients. Participants will be surveyed for survival and tumor recurrence up to 5 years after surgery.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Intrahepatic Cholangiocarcinoma (Icc) | Intrahepatic Cholangiocarcinoma | ONTOLOGY_EXACT | 0.85 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| No Interventions | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- label
- intratumoral high-fibrosis group
- interventionNames
- Other: No Interventions
- label
- intratumoral low-fibrosis group
- interventionNames
- Other: No Interventions
- label
- α-SMA high-expression group
- interventionNames
- Other: No Interventions
- label
- α-SMA low-expression
- interventionNames
- Other: No Interventions
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Patients who underwent radical resection of liver tumors in our center and obtained surgical specimens; * ICC was diagnosed by postoperative pathology Exclusion Criteria: * Patients had received radiotherapy, chemotherapy, intervention and other treatments for liver tumors before surgery * The tumor sections could not be obtained due to the loss of wax blocks or most of the defects of pathological specimens * No upper abdominal Gd-EOB-DTPA-enhanced MRI examination in our center within one month before surgery * Poor image quality or incomplete image data
References
Publications (0)
Data not yet available