Clinical trial · Interventional
SUPPORT+ Digital Self-Management and Clinical Support for Advanced Cancer
SUPPORT+ Digital Self-Management and Clinical Support for Patients With Advanced Cancer in the Community: A Randomized Controlled Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this clinical trial is to learn whether SUPPORT+, a digital symptom monitoring and self-management mobile application, can improve health-related quality of life and clinical outcomes in adults with advanced cancer receiving palliative care. The main questions this study aims to answer are: * Does use of SUPPORT+ help maintain or improve health-related quality of life compared with usual palliative care? * Does SUPPORT+ reduce functional decline and acute health care use, such as hospitalisations, compared with usual care? Researchers will compare patients using the SUPPORT+ mobile application with patients receiving usual palliative care to see if digital symptom monitoring combined with automated self-management guidance and nurse follow-up improves patient-reported and clinical outcomes. Participants assigned to the SUPPORT+ arm will: * Use the SUPPORT+ mobile application for weekly symptom reporting using the Integrated Palliative Care Outcome Scale (IPOS) * Receive automated self-management advice based on reported symptoms * Receive follow-up contact from a nurse when severe or concerning symptoms are identified * Continue to receive usual palliative care throughout the study period Participants assigned to the usual care arm will: * Receive usual palliative care provided by their clinical team * Complete study assessments at scheduled time points * Not receive digital symptom monitoring, automated self-management advice, or nurse follow-up through the SUPPORT+ application
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Advanced Cancer | Malignant Neoplasm | CURATED_BROADER | 0.78 |
| Palliative Care | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| SUPPORT+ Digital Symptom Monitoring and Clinical Support | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- SUPPORT+ Plus Usual Palliative Care
- description
- Participants in this arm receive usual palliative care supplemented by SUPPORT+, a mobile application providing weekly digital symptom monitoring, automated self-management guidance, and nurse follow-up for severe symptoms, for a duration of 18 weeks. After each submission, participants received symptom-specific self-management advice. Any report containing a severe symptom was transmitted in real time to palliative care nurses, who contacted patients within one working day during office hours to provide clinical support, including medication adjustments, self-management strategies, expedited appointments, or advice to attend the emergency department or admit to hospital. Participants could also contact nurses during office hours via the "Nurse Consult" feature; outside these hours, they were advised to seek urgent medical care.
- interventionNames
- Behavioral: SUPPORT+ Digital Symptom Monitoring and Clinical Support
- type
- NO_INTERVENTION
- label
- Usual Palliative Care
- description
- Participants in this arm receive usual palliative care provided by their clinical team according to standard practice, without access to digital symptom monitoring, automated self-management guidance, or nurse follow-up through the SUPPORT+ application. They could access only the publicly available educational materials within the SUPPORT+ application.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adults aged 18 years or older * Diagnosis of advanced malignancy * Decision not to pursue further systemic anticancer treatment * Receiving follow-up care at a participating palliative care clinic * Community-dwelling * Ownership of a smartphone * Adequate cognitive capacity to provide informed consent * Willingness to receive notifications from the SUPPORT+ mobile application * Presence of at least one symptom related to advanced cancer * Ability for the patient or a designated primary caregiver to use the mobile application Exclusion Criteria: * Receiving systemic anticancer therapy with radical or palliative intent * Estimated life expectancy of less than 3 months * Eastern Cooperative Oncology Group (ECOG) performance status greater than 3
References
Publications (1)
- DERIVEDChan WL, Soong IS, Lim MY, Tin WW, Siu SW, Ng J, Leung C, Leung A, Tai YL, Lam CM, Hou LY, Lo R, Lee VH, Yuen KK, Kwong D, Hui R. Digital Self-Management of Symptoms and Quality of Life for Patients With Advanced Cancer: A Randomized Clinical Trial. JAMA Netw Open. 2026 Jun 1;9(6):e2615509. doi: 10.1001/jamanetworkopen.2026.15509. PMID 42224222