Clinical trial · Observational
Hemiarthroplasty for Elderly With Proximal Humeral Mets
The Application of Hemiarthroplasty in Elderly Patients With Proximal Humeral Metastases
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Bone metastases are common in patients with advanced cancer and frequently involve the proximal humerus, leading to severe pain and loss of shoulder function. Shoulder arthroplasty is an important surgical option for restoring limb function and relieving pain in these patients. However, elderly patients often have multiple comorbidities, and it remains unclear whether age affects surgical outcomes and prognosis after arthroplasty for proximal humeral metastases. This retrospective observational study reviewed patients with isolated proximal humeral metastases who underwent shoulder arthroplasty at our institution. Patients were divided into elderly and younger groups based on age, and clinical outcomes were compared between the groups. Evaluated outcomes included operative characteristics, postoperative pain, limb function, complications, survival, recurrence, and quality of life. The aim of this study is to determine whether age influences prognosis and functional recovery after shoulder arthroplasty for proximal humeral metastases, and to assess the feasibility and effectiveness of this surgical procedure in elderly patients.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Bone Metastases of a Malignant Tumor | — | UNRESOLVED | — |
| Metastatic Bone Tumor | Bone Neoplasm | CURATED_BROADER | 0.78 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Proximal Humeral Hemiarthroplasty | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Elderly Patients (≥65 Years)
- description
- Patients aged 65 years or older with solitary proximal humeral metastases who underwent proximal humeral hemiarthroplasty at our institution.
- interventionNames
- Procedure: Proximal Humeral Hemiarthroplasty
- label
- Younger Patients (<65 Years)
- description
- Patients younger than 65 years with solitary proximal humeral metastases who underwent proximal humeral hemiarthroplasty at our institution.
- interventionNames
- Procedure: Proximal Humeral Hemiarthroplasty
Primary outcomes (1)
- measure
- (ASES) Score
- timeFrame
- Postoperative follow-up (up to 24 months)
- description
- Shoulder Function Assessed by the American Shoulder and Elbow Surgeons (ASES) Score
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Patients with a single metastatic lesion in the proximal humerus, confirmed by imaging or biopsy. Presence of pathological fracture or a severe osteolytic lesion at risk of fracture (Mirels score ≥9). Poor response to radiotherapy according to RECIST 1.1 criteria. Persistent severe shoulder pain or significant loss of shoulder function. Estimated life expectancy \>3 months at the time of surgery.. Exclusion Criteria: * Patients with multiple bone metastases involving two or more skeletal sites. Metastatic lesions affecting the scapula, axillary nerve, or brachial plexus. Death during the perioperative period. Presence of three or more significant comorbidities, such as uncontrolled diabetes, severe cardiopulmonary disease, or chronic renal failure. Loss to follow-up within 3 months after surgery.
References
Publications (0)
Data not yet available