Clinical trial · Interventional
Skin Involvement in Dupuytren Surgical Treatment Outcome
Skin Involvement in Dupuytren Surgical Treatment Outcome: Interventional Study on Prognostic Value of Cutometry, Ultrasound and Histopathology
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Palmar skin is often retracted in Dupuytren disease (DD), making surgical management challenging and skin-preserving surgery difficult. Based on clinical experience in DD surgery and outcome, it is suspected that recurrence may be associated with such retracted skin. Possibly, this is due to presence and persistence of aligned myofibroblasts (MF), fixed to the deepest dermal layers. This interventional study aims to investigate the pathophysiological involvement of palmar skin in Dupuytren disease, and its implications for prognostics and treatment.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Dupuytren Disease | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Microbiopsy for histological analysis | Procedure | — | UNRESOLVED |
| Suction cutometry | Diagnostic Test | — | UNRESOLVED |
| Ultrasound measurement | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- Patients with Dupuytren disease
- description
- 50 patients scheduled for microfasciectomy will be enrolled.
- interventionNames
- Diagnostic Test: Suction cutometry
- Diagnostic Test: Ultrasound measurement
- Procedure: Microbiopsy for histological analysis
Primary outcomes (1)
- measure
- Total Passive Extension Deficit (TPED) 3 months post-operative
- timeFrame
- From Baseline to 3 months post-operative
- description
- The Extension capability at 3 months post-microfasciectomy. Extension deficit is measured with a goniometer, shown in degrees (°)
Secondary outcomes (7)
- measure
- Total Passive Extension Deficit (TPED) 12 months post-operative
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Voluntary written informed consent of the participant or their legally authorized representative has been obtained prior to any screening procedures. 2. Patients ≥ 18 years old, diagnosed with primary Dupuytren disease. 3. Patients must be scheduled for microfasciectomy. Exclusion Criteria: 1. Earlier Dupuytren surgery in the hand scheduled for microfasciectomy 2. Patient's unable to give a written participating consent. 3. Younger than 18 years of age.
References
Publications (0)
Data not yet available