Intraperitoneal PX in Combination With Nab-Paclitaxel in Patients With Peritoneal Metastatic Mucinous Adenocarcinoma

Inclusion Criteria:

* Age ≥ 18 years, regardless of sex;
* Histologically confirmed peritoneal metastatic mucinous adenocarcinoma;
* Considered suitable for intraperitoneal therapy based on investigator assessment;
* ECOG performance status 0-2;
* Adequate organ function confirmed by laboratory tests within 7 days prior to enrollment:
* Hematology: ANC ≥ 1.5 × 10⁹/L; PLT ≥ 100 × 10⁹/L; Hb ≥ 85 g/L; Liver function: TBIL ≤ 1.5 × ULN (≤ 3 × ULN for Gilbert's syndrome);AST/ALT ≤ 3 × ULN (≤ 5 × ULN in patients with liver metastases); Renal function: creatinine clearance ≥ 60 mL/min (Cockcroft-Gault) or serum creatinine ≤ 1.5 × ULN; Coagulation: PT, INR, and APTT ≤ 1.5 × ULN;
* Life expectancy ≥ 3 months;
* Ability to understand and willingness to sign written informed consent.

Exclusion Criteria:

* Planned concomitant systemic anti-tumor therapy during intraperitoneal treatment;
* Massive ascites not expected to be adequately drained prior to dosing;
* Chemotherapy or radiotherapy within 4 weeks prior to enrollment (≥ 6 weeks for nitrosoureas or mitomycin C);
* Pregnancy or lactation, or unwillingness to use effective contraception;
* Severe abdominal infection or gastrointestinal obstruction;
* Known peritoneal adhesions deemed unsuitable for catheter placement;
* Active bleeding, uncorrected coagulation disorders, or inability to safely interrupt therapeutic anticoagulation;
* Known hypersensitivity to PX, nab-paclitaxel, or excipients;
* Pre-existing ≥ Grade 2 peripheral sensory neuropathy;
* Severe or uncontrolled comorbidities that may increase study risk or interfere with evaluation;
* Active or severe autoimmune disease, or ongoing systemic immunosuppressive therapy;
* Positive for HBsAg, anti-HCV, syphilis antibody, or HIV antibody;
* Psychiatric or cognitive disorders affecting compliance;
* Any other condition deemed unsuitable by the investigator.