Clinical trial · Interventional
Comparative Effect of Myo-inositol With That of D-chiro-inositol on Insulin Resistance in Infertile Women With Polycystic Ovary Syndrome (PCOS).
Effect of Myo-inositol Compared to D-chiro-inositol on Insulin Resistance in Infertile Women With Polycystic Ovary Syndrome: A Non-inferiority Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This randomized controlled trial was conducted in the Department of Reproductive Endocrinology and Infertility, BSMMU.A total of 80 infertile women ofPCOS withinsulinresistanceparticipatedinthestudyandwere randomly allocated into 2 groups. One group was treated with tab. Myoinositol (MI) 750 mg thrice daily and other group with D-chiro-inositol (DCI) 500 mg once daily for 3 months. After 3 months, follow up fasting blood sugar, fasting insulin and HOMA-IR were measured
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| PCOS (Polycystic Ovary Syndrome) | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| D-chiro-inositol 500mg | Dietary Supplement | — | UNRESOLVED |
| Tab Myo-inositol 750mg | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Experimental arm: Myoinositol Group
- description
- Myo-inositol group:Tab Myo-inositol 750mg 3 times daily for 3 months
- interventionNames
- Dietary Supplement: Tab Myo-inositol 750mg
- type
- ACTIVE_COMPARATOR
- label
- Comparator arm: D chiro-inositol group
- description
- D-chiro-inositol group: Cap D-chiro-inositol 500 mg once daily for 3 months
- interventionNames
- Dietary Supplement: D-chiro-inositol 500mg
Primary outcomes (2)
- measure
- • Fasting insulin
- timeFrame
- 12 weeks
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 35 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosed case of PCOS according to Rotterdam criteria * Primary or secondary infertility * Insulin resistance (HOMA-IR \>2) Exclusion Criteria: * Age less than 18 years and more than 35 years * BMI less than 18.5kg/ m² and more than 30 kg/ m² * Endocrine disorders (Diabetes mellitus, hypothyroidism, hyperprolactinemia) * Any contraindications to MI or DCI * Any insulin sensitizer (metformin or inositol) in the last three months
References
Publications (2)
- RESULTGenazzani AD, Santagni S, Rattighieri E, Chierchia E, Despini G, Marini G, Prati A, Simoncini T. Modulatory role of D-chiro-inositol (DCI) on LH and insulin secretion in obese PCOS patients. Gynecol Endocrinol. 2014 Jun;30(6):438-43. doi: 10.3109/09513590.2014.897321. Epub 2014 Mar 7. PMID 24601829
- RESULTMerviel P, Bouee S, Menard M, Le Martelot MT, Roche S, Lelievre C, Chabaud JJ, Jacq C, Drapier H, Beauvillard D. [Which ovarian stimulation to which women: The polycystic ovary syndrome (PCOS)]. Gynecol Obstet Fertil Senol. 2017 Nov;45(11):623-631. doi: 10.1016/j.gofs.2017.10.001. French. PMID 29100822