Clinical trial · Observational
Registry Study of People Who Are Having an Esophagectomy and Are at High Risk of Anastomotic Leak
Gastric Preconditioning by Percutaneous Angioembolization Before Esophagectomy in Patients With a High Risk of Anastomotic Leak
NCT07449208CI-TRIAL-00104630recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The main purpose of this study is to look at how often anastomotic leaks happen in participants who are at high risk of these leaks and are eligible to receive gastric preconditioning by percutaneous angioembolization before an esophagectomy.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anastomotic Leak | — | UNRESOLVED | — |
| Esophageal Malignant Neoplasm Primary | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Esophagectomy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Participants Who Are Having an Esophagectomy and Are at High Risk of Anastomotic Leak
- description
- Participants who are undergoing preoperative gastric preconditioning by percutaneous angioembolization before esophagectomy for esophageal malignancy and who have a high risk of anastomotic leak
- interventionNames
- Procedure: Esophagectomy
Primary outcomes (1)
- measure
- Incidence of anastomotic leak
- timeFrame
- 1 year
- description
- Determine the incidence of anastomotic leak among participants with a high risk of esophageal leak who undergo esophagectomy after preoperative gastric preconditioning by percutaneous angioembolization.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Documentation of Disease * Patients must have pathologically confirmed esophageal malignancy requiring esophagectomy. * Patients must also have risk factors for anastomotic leak: * Previous foregut or bariatric surgery (gastric sleeve or gastric bypass), but excluding fundoplication-only surgery OR * Salvage esophagectomy OR * Planned cervical anastomosis OR * Two or more comorbidities: * Diabetes, obesity, coronary artery disease, vascular disease (including celiac stricture or atherosclerosis, significant aortic disease, or any previous diagnosis of peripheral arterial disease), steroid use, hypertension, current or former smoker, renal insufficiency, and heart failure. * Definition of Disease * Patients must have pathologically confirmed esophageal malignancy requiring esophagectomy and risk factors for anastomotic leak, as described above. * Patients must be candidate and have agreed to receive gastric preconditioning procedure * Prior Treatment o There are no requirements with regard to prior treatment. * Age ≥ 18 * ECOG Performance Status of ≤ 2 (See Appendix I for performance status criteria)
References
Publications (0)
Data not yet available
No reference posted for this study.