Clinical trial · Interventional
Magnesium vs. Dexmedetomidine in TURBT Under Spinal Anesthesia
A Randomized Controlled Trial of the Analgesic, Hemodynamic, and Respiratory Effects of Intravenous Magnesium Sulfate and Dexmedetomidine Infusions During Transurethral Bladder Tumor Resection Under Spinal Anesthesia
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This randomized controlled trial evaluated the effects of intraoperative intravenous magnesium sulfate versus dexmedetomidine on postoperative pain, analgesic consumption, hemodynamic stability, and respiratory function in patients undergoing elective transurethral resection of bladder tumor (TUR-M) under spinal anesthesia. Magnesium sulfate significantly reduced postoperative pain scores, delayed the time to first analgesic request, and decreased total analgesic consumption compared to dexmedetomidine and control groups, while both agents were hemodynamically and respiratorily safe.
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Bladder Tumors | Bladder Neoplasm | ALIAS | 0.90 |
| Dexmedetomidine | — | UNRESOLVED | — |
| Hemodynamic and Respiratory Monitoring | — | UNRESOLVED | — |
| Magnesium Sulfate | — | UNRESOLVED | — |
| Postoperative Pain | — | UNRESOLVED | — |
| Spinal Anesthesia | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dexmedetomidine | Drug | — | UNRESOLVED |
| magnesium sulfate | Drug | — | UNRESOLVED |
| Normal Saline | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- Magnesium Sulfate Infusion Group
- description
- Patients receive intravenous magnesium sulfate at 15 mg/kg/hour during TUR-M surgery under spinal anesthesia. Infusion solution is prepared aseptically by diluting the calculated dose in 50 mL of 0.9% NaCl. Postoperative analgesia is administered as rescue treatment based on VAS scores.
- interventionNames
- Drug: magnesium sulfate
- type
- EXPERIMENTAL
- label
- Dexmedetomidine Infusion Group
- description
- Patients receive intravenous dexmedetomidine at 0.5 µg/kg/hour during TUR-M surgery under spinal anesthesia. The calculated dose is diluted in 50 mL of 0.9% NaCl and infused intravenously. Postoperative analgesia is given as rescue treatment according to VAS scores.
- interventionNames
- Drug: Dexmedetomidine
- type
- ACTIVE_COMPARATOR
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 85 Years
Show eligibility criteria text
Inclusion Criteria: Age between 18 and 85 years. Classified as ASA physical status I, II, or III according to the American Society of Anesthesiologists. Patients scheduled for elective transurethral resection of bladder tumor (TUR-M) under spinal anesthesia. Exclusion Criteria: Patients under 18 years or over 85 years of age. Contraindications to spinal anesthesia (e.g., infection at puncture site, coagulopathy). History or current diagnosis of significant cardiac arrhythmia. Known allergy or contraindication to the study drugs (magnesium sulfate or dexmedetomidine). Patients requiring conversion to general anesthesia due to inadequate spinal anesthesia intraoperatively. Mental retardation, cognitive impairment, or communication difficulties that prevent understanding of study procedures or pain assessment. Patients who refuse to participate in the study. \-
References
Publications (0)
Data not yet available