Impact of Exercise Intensity on Cardiac Health in Young Adult Survivors of Childhood Cancer: The PULSE Trial

Inclusion Criteria:

* Current age at study initiation 18-39 years.
* Cancer diagnosis at age ≤ 18 years.
* Previous exposure to any dose of anthracyclines.
* Are ≥2 years post-treatment and in remission without relapse after cancer directed therapy.
* Eastern Cooperative Oncology Group Performance Status = 0
* Oncology survivorship provider clearance to participate in exercise
* No self-reported comorbidities or contraindications that prohibit the undertaking of high intensity exercise (e.g., severe valvular heart disease)
* Sedentary (i.e., currently participates in ≤ 60 minutes of structured high or moderate intensity exercise/week) determined by self-report during screening using the Godin Leisure Time Exercise Questionnaire
* Speak English
* Willing to travel to Dana-Farber Cancer Institute for necessary data collection

Exclusion Criteria:

* Unstable comorbidities that prevent participation in moderate-to-vigorous intensity exercise.
* Patients who are pregnant.
* Participate in more than 60 minutes of structured moderate-to-vigorous exercise per week over the last month.
* Patients receiving treatment for other active malignancies (except basal cell carcinoma).
* Subjects who in the opinion of the investigators, may not be able to comply with the safety monitoring requirements of the study.
* Unable to travel to DFCI Longwood campus for necessary data collection.