Clinical trial · Interventional
Lavender Aromatherapy for Preoperative Anxiety in Melanoma and Epithelioma Patients
Benefits of Lavender Essential Oil Aromatherapy in the Management of Preoperative Anxiety in Patients Undergoing Surgical Excision of Melanoma or Epithelioma: A Prospective Randomized Study
NCT07434323CI-TRIAL-00103990LAPAMcompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This double-blind, randomized, placebo-controlled trial evaluates whether a single 15-minute session of inhalational lavender aromatherapy, administered preoperatively, reduces anxiety in adult patients (ASA I-II) scheduled for surgical radicalization of pT1a melanoma or epithelioma. Physiological parameters (blood pressure, heart rate, respiratory rate) and validated psychometric scales (DASS-21, STAI Y-1 and Y-2) will be recorded at defined time points before and after the intervention. Total planned enrollment: 66 participants
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Melanoma | Melanoma | ONTOLOGY_EXACT | 0.98 |
| Non-Melanoma Skin Cancer | Skin Carcinoma | ALIAS | 0.90 |
| Preoperative Anxiety | — | UNRESOLVED | — |
| pT1a | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Lavender Essential Oil | Drug | — | UNRESOLVED |
| Physiological saline solution (as placebo) | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Lavender aromatherapy
- description
- Participants receive inhalational lavender essential oil aromatherapy for 15 minutes in the preoperative ward using a dedicated diffuser, prior to surgery for melanoma or non-melanoma skin cancer. Anxiety levels are assessed using validated psychometric scales and physiological parameters at predefined time points.
- interventionNames
- Drug: Lavender Essential Oil
- type
- PLACEBO_COMPARATOR
- label
- Placebo (Physiological Saline)
- description
- Participants receive inhalational physiological saline for 15 minutes in the preoperative ward using an identical diffuser, prior to surgery for melanoma or non-melanoma skin cancer. Anxiety levels are assessed using validated psychometric scales and physiological parameters at predefined time points.
- interventionNames
- Drug: Physiological saline solution (as placebo)
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Adults aged 18 to 80 years * Patients diagnosed with pT1a melanoma or non-melanoma skin cancer (epithelioma) * Scheduled for surgical radicalization under local anesthesia * American Society of Anesthesiologists (ASA) physical status classification I or II * Ability to understand and complete self-administered questionnaires (STAI Y-1, STAI Y-2, DASS-21) * Willingness and ability to provide written informed consent Exclusion Criteria * Known allergy or hypersensitivity to lavender or essential oils * Current use of anxiolytic, antidepressant, or psychotropic medications * History of psychiatric disorders or ongoing psychological treatment * Cognitive impairment or inability to complete questionnaires independently * Pregnancy or breastfeeding * Severe respiratory diseases (e.g., asthma, COPD) that could interfere with inhalational aromatherapy * ASA physical status classification ≥ III * Participation in another interventional clinical trial at the same time
References
Publications (7)
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- BACKGROUNDBeyliklioglu A, Arslan S. Effect of Lavender Oil on the Anxiety of Patients Before Breast Surgery. J Perianesth Nurs. 2019 Jun;34(3):587-593. doi: 10.1016/j.jopan.2018.10.002. Epub 2019 Jan 16. PMID 30660371
- BACKGROUNDYang EJ, Lipner SR. Differences in price trends between branded and generic medications for onychomycosis. Dermatol Ther. 2020 Nov;33(6):e13928. doi: 10.1111/dth.13928. Epub 2020 Jul 13. No abstract available. PMID 32602157
- BACKGROUNDTofield A. Peace Plaque for the city of Barcelona. Eur Heart J. 2018 Feb 14;39(7):502. doi: 10.1093/eurheartj/ehy032. No abstract available. PMID 29452414
- BACKGROUNDWhichello C, Bywall KS, Mauer J, Stephen W, Cleemput I, Pinto CA, van Overbeeke E, Huys I, de Bekker-Grob EW, Hermann R, Veldwijk J. An overview of critical decision-points in the medical product lifecycle: Where to include patient preference information in the decision-making process? Health Policy. 2020 Dec;124(12):1325-1332. doi: 10.1016/j.healthpol.2020.07.007. Epub 2020 Jul 30. PMID 32839011
- BACKGROUNDWainwright BJ, Zahn GL, Zushi J, Lee NLY, Ooi JLS, Lee JN, Huang D. Seagrass-associated fungal communities show distance decay of similarity that has implications for seagrass management and restoration. Ecol Evol. 2019 Sep 15;9(19):11288-11297. doi: 10.1002/ece3.5631. eCollection 2019 Oct.