Clinical trial · Interventional
Effect of Rectus Block Timing on Opioid Use
The Effect of Timing of Rectus Sheath Blockade During Robotic Prostate Surgery on Opioid Consumption: A Randomized Double-Blind Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of this study is to observe the effect of administering local anesthetic to the abdominal wall at the beginning or end of surgery under general anesthesia on opioid consumption during surgery. The hypothesis of this study is to demonstrate that administering a rectus sheath block before the surgical procedure under general anesthesia is effective in reducing intraoperative opioid consumption and opioid-related side effects compared to administering it after the surgery is completed.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Nociception Level Index(NoL) | — | UNRESOLVED | — |
| Nociception Monitoring | — | UNRESOLVED | — |
| Opioid Consumption | — | UNRESOLVED | — |
| Pain Management | — | UNRESOLVED | — |
| Prostate Cancer | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Early bilateral rectus sheat block | Procedure | — | UNRESOLVED |
| Late bilateral rectus sheat block | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Preoperative RSB Group
- description
- The group of patients undergoing robotic prostatectomy surgery who received a rectus sheath block prior to the surgical procedure
- interventionNames
- Procedure: Early bilateral rectus sheat block
- type
- ACTIVE_COMPARATOR
- label
- Postoperative RSB Group
- description
- The group of patients undergoing robotic prostatectomy surgery who received a rectus sheath block after the surgical procedure
- interventionNames
- Procedure: Late bilateral rectus sheat block
Primary outcomes (2)
- measure
- Total intraoperatif remifentanil consumption
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: -ASA (American Society of Anesthesiologists) I-III adult patients with prostate cancer and benign prostate diseases scheduled for robotic surgery at Koç University Hospital. Exclusion Criteria: * \<18 years of age * ASA (American Society of Anesthesiologists) IV, V patients * Non-elective emergency cases * Previous major abdominal/pelvic surgery * History of significant psychiatric disorders * Patients who may have contraindications to nerve blocks (bleeding diathesis, infection, and local anesthetic allergy).
References
Publications (5)
- BACKGROUNDFuncke S, Pinnschmidt HO, Brinkmann C, Wesseler S, Beyer B, Fischer M, Nitzschke R. Nociception level-guided opioid administration in radical retropubic prostatectomy: a randomised controlled trial. Br J Anaesth. 2021 Feb;126(2):516-524. doi: 10.1016/j.bja.2020.09.051. Epub 2020 Nov 20. PMID 33228979
- BACKGROUNDMeijer FS, Martini CH, Broens S, Boon M, Niesters M, Aarts L, Olofsen E, van Velzen M, Dahan A. Nociception-guided versus Standard Care during Remifentanil-Propofol Anesthesia: A Randomized Controlled Trial. Anesthesiology. 2019 May;130(5):745-755. doi: 10.1097/ALN.0000000000002634. PMID 30829658
- BACKGROUNDLumme A, Kalliomaki ML, Harju J, Nordstrom P. Combining Transversus Abdominis Plane and Rectus Sheath Blocks in Open Inguinal Hernia Surgery Anesthesia: A Retrospective Cohort Analysis. World J Surg. 2025 Mar;49(3):626-633. doi: 10.1002/wjs.12481. Epub 2025 Jan 23. PMID 39853690
- BACKGROUNDCosarcan SK, Gurkan Y, Manici M, Ozdemir I, Kilic M, Esen T, Ercelen O. The effect of ultrasound-guided rectus sheath block on postoperative analgesia in robot assisted prostatectomy: A randomized controlled trial. Medicine (Baltimore). 2024 Apr 26;103(17):e37975. doi: 10.1097/MD.0000000000037975. PMID 38669407
- BACKGROUNDLavand'homme P, Steyaert A. Opioid-free anesthesia opioid side effects: Tolerance and hyperalgesia. Best Pract Res Clin Anaesthesiol. 2017 Dec;31(4):487-498. doi: 10.1016/j.bpa.2017.05.003. Epub 2017 May 17. PMID 29739537