Clinical trial · Observational
Role of Arterial Spin Labelling Magnetic Resonance Prefusion in Grading of Pediatric Brain Tumors
Role of Arterial Spin Labelling Magnetic Resonance Perfusion in The Grading of Pediatric Brain Tumors
NCT07427316CI-TRIAL-00103852not yet recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To evaluate the diagnostic performance of arterial spin labelling (ASL) magnetic resonance perfusion in preoperative grading of pediatric brain tumors.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pediatric Brain Tumors | Childhood Brain Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (2)
- label
- low grade pediatric brain tumors
- label
- high grade pediatric brain tumors
Primary outcomes (1)
- measure
- Evaluate the diagnostic value of arterial spin labelling (ASL) magnetic resonance perfusion in pre-operative grading of pediatric brain tumors
- timeFrame
- preoperative
- description
- arterial spin labelling (ASL) derived cerebral blood flow values and their correlation with histopathological tumor grade (low grade versus high grade pediatric brain tumor)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 0 Years
- Maximum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Pediatric patients aged 18 years or younger. 2. Patients with radiological diagnosis of intracranial brain tumors. Exclusion Criteria: 1. Patients who have received prior surgery, chemotherapy or radiotherapy for brain tumors. 2. Patients with contraindications to magnetic resonance imaging (MRI) examination.
References
Publications (5)
- BACKGROUNDKong L, Chen H, Yang Y, Chen L. A meta-analysis of arterial spin labelling perfusion values for the prediction of glioma grade. Clin Radiol. 2017 Mar;72(3):255-261. doi: 10.1016/j.crad.2016.10.016. Epub 2016 Dec 6. PMID 27932251
- BACKGROUNDMorana G, Tortora D, Stagliano S, Nozza P, Mascelli S, Severino M, Piatelli G, Consales A, Lequin M, Garre ML, Rossi A. Pediatric astrocytic tumor grading: comparison between arterial spin labeling and dynamic susceptibility contrast MRI perfusion. Neuroradiology. 2018 Apr;60(4):437-446. doi: 10.1007/s00234-018-1992-6. Epub 2018 Feb 16. PMID 29453753
- BACKGROUNDDangouloff-Ros V, Deroulers C, Foissac F, Badoual M, Shotar E, Grevent D, Calmon R, Pages M, Grill J, Dufour C, Blauwblomme T, Puget S, Zerah M, Sainte-Rose C, Brunelle F, Varlet P, Boddaert N. Arterial Spin Labeling to Predict Brain Tumor Grading in Children: Correlations between Histopathologic Vascular Density and Perfusion MR Imaging. Radiology. 2016 Nov;281(2):553-566. doi: 10.1148/radiol.2016152228. Epub 2016 Jun 3. PMID 27257950
- BACKGROUNDFurtner J, Schopf V, Schewzow K, Kasprian G, Weber M, Woitek R, Asenbaum U, Preusser M, Marosi C, Hainfellner JA, Widhalm G, Wolfsberger S, Prayer D. Arterial spin-labeling assessment of normalized vascular intratumoral signal intensity as a predictor of histologic grade of astrocytic neoplasms. AJNR Am J Neuroradiol. 2014 Mar;35(3):482-9. doi: 10.3174/ajnr.A3705. Epub 2013 Aug 14. PMID 23945226
- BACKGROUNDYeom KW, Mitchell LA, Lober RM, Barnes PD, Vogel H, Fisher PG, Edwards MS. Arterial spin-labeled perfusion of pediatric brain tumors. AJNR Am J Neuroradiol. 2014 Feb;35(2):395-401. doi: 10.3174/ajnr.A3670. Epub 2013 Aug 1. PMID 23907239