Clinical trial · Interventional
Development of an Integrated Multi-channel Artificial Nose for Cancer Detection (UNos)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This interventional diagnostic study evaluated a multi-channel artificial nose (UNos) medical device for analysis of exhaled breath in participants with head and neck squamous cell carcinoma and healthy volunteers. Participants underwent a standardized breath sampling procedure, and exhaled air was analyzed using semi-selective sensor arrays to generate quantitative breath pattern signatures. The study evaluated the ability of the device to discriminate cancer participants from healthy controls based on sensor-derived breath profiles.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Head and Neck Cancer | Malignant Head and Neck Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Artificial or Electronic Nose (E-Nose) medical device | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Head and Neck Cancer Participants - Breath Analysis
- description
- Participants with histologically confirmed head and neck squamous cell carcinoma underwent a standardized exhaled breath sampling procedure according to study protocol. Breath samples were collected into gas sampling bags under controlled conditions and analyzed using a multi-channel artificial nose (UNos) medical device equipped with semi-selective chemical sensors. The device generated quantitative sensor response values representing volatile organic compound patterns in exhaled air. No therapeutic intervention was performed, and the procedure did not influence clinical management.
- interventionNames
- Device: Artificial or Electronic Nose (E-Nose) medical device
- type
- EXPERIMENTAL
- label
- Healthy Volunteers - Breath Analysis
- description
- Healthy adult volunteers underwent the same standardized exhaled breath sampling procedure as cancer participants. Breath samples were collected into gas sampling bags and analyzed using the multi-channel artificial nose (UNos) system to obtain quantitative sensor response patterns. The procedure was non-invasive and performed for diagnostic signal acquisition only, without any therapeutic intervention.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria:
* Healthy volunteers.
* Non-smokers and smokers
* Aged over 18 years.
* The person must be able to understand and sign the consent form for participation in the clinical trial ("informed consent").
Exclusion Criteria:
* Throat or pharyngeal cancer that is not squamous cell carcinoma
* Known malignant disease elsewhere in the body.
* Previously treated malignant disease anywhere in the body, with the exception of non-melanoma skin cancer or cervical CIS
* Diabetes.
* Age under 18 years.References
Publications (0)
Data not yet available