Clinical trial · Observational
Mental Health and Suicidality in Glioblastoma Patients in Germany
Mental Health and Suicidality in Glioblastoma Patients in Germany - a Multicenter Observational Study (SHINE-GLIO Study)
NCT07409584CI-TRIAL-00124070SHINE-GLIOrecruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of the study is to use standardized questionnaires to systematically record influencing factors or predictors for suicidal behavior in glioblastoma patients, particularly with regard to existing depression and anxiety symptoms.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Glioblastoma (GBM) | Glioblastoma | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Medical history, physical examination, completing questionnaires, data collection | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- glioblastoma patients
- description
- primary disease or recurrence
- interventionNames
- Diagnostic Test: Medical history, physical examination, completing questionnaires, data collection
Primary outcomes (1)
- measure
- Suicidality
- timeFrame
- in the last 4 weeks before participating in the study
- description
- Measured using a questionnaire
Secondary outcomes (4)
- measure
- Depression
- timeFrame
- in the last 2 weeks before participating in the study
- description
- Measured using a questionnaire
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Newly diagnosed glioblastoma, IDH wild-type (CNS WHO classification of 2021) after finishing radiotherapy (before first recurrence) * Age ≥ 18 years Exclusion Criteria: * Participants with clinically significant aphasia or language barrier as assessed by the investigator * History of other malignant tumors * Known tumor predisposition syndrome (e.g., Li-Fraumeni syndrome, Cowden syndrome, etc.) * Recurrent glioblastoma
References
Publications (10)
- BACKGROUNDRenovanz M, Hippler M, Kuchen R, Doerner L, Rieger D, Steinbach JP, Ronellenfitsch MW, Voss M, Kessler AF, Nickl V, Misch M, Onken JS, Rapp M, Nadji-Ohl M, Mehlitz M, Meixensberger J, Fehrenbach MK, Keric N, Ringel F, Coburger J, Lucas CW, Wehinger J, Schmidt-Graf F, Gempt J, Tatagiba M, Tabatabai G, Schranz M, Singer S. Physician-led versus questionnaire-based psychosocial screening in adults with high-grade glioma: a cluster-randomized controlled trial (GLIOPT). J Neurooncol. 2025 Dec;175(3):967-977. doi: 10.1007/s11060-025-05223-6. Epub 2025 Sep 10. PMID 40931258
- BACKGROUNDCostanza A, Zenga F, Ruda R, Amerio A, Aguglia A, Serafini G, Amore M, Bondolfi G, Berardelli I, Nguyen KD. Suicidality in Patients with Brain Tumors: A Brief Literature Review with Clinical Exemplar. Medicina (Kaunas). 2020 Dec 21;56(12):725. doi: 10.3390/medicina56120725. PMID 33371470
- BACKGROUNDHeinrich M, Hofmann L, Baurecht H, Kreuzer PM, Knuttel H, Leitzmann MF, Seliger C. Suicide risk and mortality among patients with cancer. Nat Med. 2022 Apr;28(4):852-859. doi: 10.1038/s41591-022-01745-y. Epub 2022 Mar 28. PMID 35347279
- BACKGROUNDZaorsky NG, Zhang Y, Tuanquin L, Bluethmann SM, Park HS, Chinchilli VM. Suicide among cancer patients. Nat Commun. 2019 Jan 14;10(1):207. doi: 10.1038/s41467-018-08170-1. PMID 30643135
- BACKGROUNDDong J, Chen Q, Weng S, Liu L, Wang J, Fang S, Fan X, Jiang T. The effect of depression and anxiety on survival in patients with glioma: a systematic review and meta-analysis. J Neurooncol. 2024 Nov;170(2):265-275. doi: 10.1007/s11060-024-04799-9. Epub 2024 Sep 3. PMID 39225956
- BACKGROUNDLitofsky NS, Farace E, Anderson F Jr, Meyers CA, Huang W, Laws ER Jr; Glioma Outcomes Project Investigators. Depression in patients with high-grade glioma: results of the Glioma Outcomes Project. Neurosurgery. 2004 Feb;54(2):358-66; discussion 366-7. doi: 10.1227/01.neu.0000103450.94724.a2.