Clinical trial · Interventional
Toxicity Outcomes of Simultaneous Integrated Boost in Adjuvant Breast Radiotherapy Acronym
Toxicity Outcomes of Simultaneous Integrated Boost as Part of Adjuvant Radiotherapy in Breast Cancer Patients After Breast-Conserving Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This prospective study systematically evaluates toxicity outcomes in breast cancer patients treated with adjuvant radiotherapy using the simultaneous integrated boost (SIB) technique after breast-conserving surgery. The aim is to monitor acute and late treatment-related side effects during implementation of this radiotherapy approach and to compare institutional toxicity outcomes with published data in the literature.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Adjuvant Breast Radiotherapy With Simultaneous Integrated Boost (SIB) | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Adjuvant Radiotherapy With Simultaneous Integrated Boost (SIB)
- description
- Breast cancer patients treated with breast-conserving surgery receive adjuvant radiotherapy to the whole breast with a simultaneous integrated boost (SIB) to the tumor bed, using either standard fractionation or hypofractionation. Acute and late toxicity outcomes are prospectively recorded.
- interventionNames
- Radiation: Adjuvant Breast Radiotherapy With Simultaneous Integrated Boost (SIB)
Primary outcomes (2)
- measure
- Acute Radiation Toxicity (CTCAE)
- timeFrame
- From start of radiotherapy up to 3 months after completion of radiotherapy
- description
- Incidence and severity of acute radiotherapy-related toxicity assessed during treatment and shortly after completion, graded according to Common Terminology Criteria for Adverse Events (CTCAE).
- measure
- Acute Radiation Toxicity (CTCAE)
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Female patients with histologically confirmed breast cancer * Status post breast-conserving surgery (lumpectomy) * Planned adjuvant whole-breast radiotherapy with simultaneous integrated boost (SIB) to the tumor bed * Age ≥ 18 years * Ability to provide informed consent Exclusion Criteria: * Prior radiotherapy to the breast or thoracic region * Mastectomy (no breast-conserving surgery) * Pregnancy or breastfeeding * Inability to complete planned radiotherapy or follow-up assessments
References
Publications (0)
Data not yet available