The Efficacy and Safety of Paclitaxel Monotherapy Versus Paclitaxel-Carboplatin Combination as Neoadjuvant Chemotherapy in Advanced Ovarian Cancer With High PARK2 Expression

Inclusion Criteria:

* Female patients aged 18-75 years.
* Histologically confirmed FIGO Stage III-IV high-grade serous or endometrioid ovarian cancer, primary peritoneal cancer, or fallopian tube cancer via laparotomy, laparoscopy, or core needle biopsy.
* Presence of at least one measurable lesion on CT/MRI, meeting at least one of the following conditions:

  * Failure to achieve R0 cytoreduction (Fagotti score ≥ 8 or upper abdominal CT score ≥ 3).
  * Presence of factors indicating surgical intolerance (meeting ≥1 item): Age ≥75 years; BMI ≥40; Chronic underlying diseases; Malnutrition or hypoalbuminemia; Moderate to large volume ascites; Newly diagnosed venous thromboembolism; ECOG performance status \>2.
* High expression of the PARK2 gene in both tumor tissue and blood (Spatial Imaging \[SI\] score in tumor tissue ≥ 7).
* Expected survival time \> 12 weeks.
* ECOG performance status of 0-2.
* Adequate organ function meeting the following criteria:

  * Bone Marrow Function: Absolute neutrophil count (ANC) ≥ 1,500/mm³ (1.5 × 10⁹/L); Platelet count ≥ 100,000/mm³ (100 × 10⁹/L); Hemoglobin ≥ 10 g/dL (100 g/L).
  * Liver Function: Total bilirubin ≤ 1.5 × upper limit of normal (ULN); Direct bilirubin ≤ 1 × ULN; AST/ALT ≤ 2.5 × ULN (≤ 5 × ULN if liver metastases are present).
  * Renal Function: Serum creatinine ≤ 1.5 × ULN or creatinine clearance ≥ 60 mL/min (calculated using the Cockcroft-Gault formula).
* For women of childbearing potential:

  * Negative pregnancy test within 1 week prior to enrollment.
  * Agreement to use effective non-hormonal contraception (e.g., barrier method/intrauterine device) during the study period.
  * Not currently breastfeeding.
* Recovery from prior chemotherapy-related toxicities to ≤ Grade 1 per CTCAE (or baseline level), except for stable sensory neuropathy or alopecia (which may be ≤ Grade 2).
* Willingness to provide tissue and blood samples during the treatment period.
* Ability to understand and voluntarily comply with the study protocol requirements, including:

  * Adherence to the prescribed treatment schedule.
  * Completion of required laboratory tests and imaging assessments per protocol.
  * Participation in the planned follow-up procedures.
* Willingness to complete quality of life questionnaire assessments.

Exclusion Criteria:

* Individuals involved in the planning or conduct of this study.
* Patients concurrently participating in other clinical trials, using other investigational drugs, or receiving neoadjuvant therapies (chemotherapy/radiotherapy/immunotherapy/traditional Chinese medicine therapy).
* Known hypersensitivity or allergy to paclitaxel or carboplatin.
* Patients with dysphagia or gastrointestinal disorders that could affect drug absorption, distribution, metabolism, or excretion (ADME).
* Active symptomatic brain metastases requiring surgery, radiation, and/or corticosteroid therapy, or patients with clinical signs of spinal cord compression.
* Major surgery within 3 weeks prior to study initiation without full recovery.
* Previous or current diagnosis of myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML) or other primary malignancies (except for adequately treated basal cell or squamous cell carcinoma of the skin, ductal carcinoma in situ of the breast, or carcinoma in situ of the cervix).
* Diseases or conditions associated with a high risk of toxicity, including:

  * HIV infection, active hepatitis B or C.
  * Severe cardiovascular diseases (e.g., refractory ventricular arrhythmia, myocardial infarction within the past 3 months).
  * Uncontrolled grand mal seizures, unstable spinal cord compression, or superior vena cava syndrome.
  * Psychiatric illness that would impair the patient's ability to provide informed consent.
  * Uncontrolled hypertension or any other condition deemed by the investigator to be unsuitable for study participation.
  * Prior medical history or existing clinical conditions that may interfere with the interpretation of study results or patient compliance.
  * Transfusion of platelets or red blood cells within 3 days prior to the start of study drug administration.
  * Unresolved clinical toxicities ≥ Grade 2 (except for neuralgia, lymphopenia, and skin depigmentation).