Clinical trial · Observational
MRI Evaluation of Spinal Cord Edema After CT-Guided Percutaneous Cordotomy in Cancer Pain Patients
Evaluation of Medulla Spinalis Edema After CT-Guided Percutaneous Cervical Cordotomy Using Magnetic Resonance Imaging and Its Association With Postprocedural Clinical Outcomes in Patients With Cancer Pain
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This observational study aims to evaluate changes in the spinal cord following CT-guided percutaneous cervical cordotomy performed for the treatment of intractable cancer-related pain. Cordotomy is a routine clinical procedure used to relieve severe pain in selected cancer patients. After the procedure, some patients may develop temporary neurological symptoms that are thought to be related to spinal cord edema. In this study, magnetic resonance imaging (MRI) will be performed as part of routine clinical follow-up on postoperative day 1 and at 1 month to assess the presence and extent of spinal cord edema. Clinical outcomes, including pain intensity and possible postprocedural symptoms, will be recorded and compared with MRI findings. The goal of this research is to better understand the relationship between imaging changes in the spinal cord and clinical outcomes after cordotomy, which may help improve patient care and postoperative management in the future.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer Pain | — | UNRESOLVED | — |
| Intractable Pain | — | UNRESOLVED | — |
| Neuropathic Pain | — | UNRESOLVED | — |
| Spinal Cord Edema | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| CT-guided Percutaneous Cervical Cordotomy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Percutaneous Cervical Cordotomy Cohort
- description
- Adult patients with cancer-related pain undergoing routine CT-guided percutaneous cervical cordotomy and followed with postoperative MRI and clinical assessments.
- interventionNames
- Procedure: CT-guided Percutaneous Cervical Cordotomy
Primary outcomes (1)
- measure
- Presence and extent of spinal cord edema on cervical MRI after CT-guided percutaneous cordotomy
- timeFrame
- Postoperative day 1 and 1 month
- description
- Spinal cord edema will be evaluated on cervical MRI by a single radiologist, including presence, location, and longitudinal extent of edema.
Secondary outcomes (1)
- measure
- Change in pain intensity measured by Numeric Rating Scale (NRS)
- timeFrame
- Baseline, postoperative day 1, and 1 month
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: Adults aged 18 years and older Patients with cancer-related pain refractory to medical treatment Patients scheduled to undergo CT-guided percutaneous cervical cordotomy as part of routine clinical care Ability to provide informed consent Availability for postoperative MRI follow-up on day 1 and at 1 month Exclusion Criteria: Patients younger than 18 years Patients without an indication for percutaneous cervical cordotomy Inability to undergo MRI (e.g., incompatible implants, severe claustrophobia) Patients who decline participation or withdraw consent Incomplete clinical or imaging follow-up data
References
Publications (3)
- BACKGROUNDKanpolat Y, Ozdemir M, Al-Beyati E. CT-guided percutaneous cordotomy for intractable pain in what is more than a disease: lung malignancies. Turk Neurosurg. 2013;23(1):81-7. doi: 10.5137/1019-5149.JTN.6980-12.0. PMID 23344872
- BACKGROUNDMercadante S. Intractable pain and cordotomy. BMJ Support Palliat Care. 2020 Sep;10(3):339. doi: 10.1136/bmjspcare-2020-002360. Epub 2020 May 20. No abstract available. PMID 32434924
- BACKGROUNDZomers PJW, Groeneweg G, Baart S, Huygen FJP. Percutaneous Cervical Cordotomy for the Treatment of Cancer Pain: A Prospective Case Series of 52 Patients with a Long-Term Follow-Up. Pain Pract. 2021 Jun;21(5):557-567. doi: 10.1111/papr.12991. Epub 2021 Jan 22. PMID 33350042