Clinical trial · Interventional
SCUBE Proteins in Polycystic Ovary Syndrome (IPSOS)
Study of Scube-1 and Scube-3 in Polycystic Ovary Syndrome (PCOS) and Their Possible Use as Inflammatory Markers and as a Link Between PCOS and Cardiovascular Events.
NCT07396402CI-TRIAL-00102802IPSOSnot yet recruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study investigates circulating levels of SCUBE-1 and SCUBE-3 proteins in women with polycystic ovary syndrome (PCOS) compared with healthy controls. Differences between normoinsulinemic and hyperinsulinemic PCOS subgroups will be evaluated, as well as correlations with clinical and metabolic parameters related to inflammation and cardiovascular risk.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Insulin Resistance | — | UNRESOLVED | — |
| Polycystic Ovary Syndrome (PCOS) | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Blood Sample Collection for SCUBE-1 and SCUBE-3 Measurement | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- Arm 1: PCOS - Normoinsulinemic
- description
- Description: Women with PCOS and normal insulin sensitivity Intervention: Blood sample collection for SCUBE-1 and SCUBE-3 measurement by ELISA
- interventionNames
- Diagnostic Test: Blood Sample Collection for SCUBE-1 and SCUBE-3 Measurement
- type
- EXPERIMENTAL
- label
- Arm 2: PCOS - Hyperinsulinemic
- description
- Description: Women with PCOS and insulin resistance Intervention: Blood sample collection for SCUBE-1 and SCUBE-3 measurement by ELISA
- interventionNames
- Diagnostic Test: Blood Sample Collection for SCUBE-1 and SCUBE-3 Measurement
- type
- EXPERIMENTAL
- label
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 35 Years
Show eligibility criteria text
Inclusion Criteria: * Female subjects aged 18-35 years * Diagnosis of polycystic ovary syndrome (normoinsulinemic or hyperinsulinemic) * Availability of basal hormonal evaluation and oral glucose tolerance test * Healthy women for control group * Written informed consent Exclusion Criteria: * Pregnancy * History of cardiovascular disease * Diabetes mellitus or impaired glucose tolerance * Hypertension * Significant hepatic or renal disease * Other endocrine disorders * Neoplastic diseases * Psychiatric disorders * Autoimmune diseases * Shift work * Obesity * Refusal to sign informed consent
References
Publications (0)
Data not yet available
No reference posted for this study.