A Platform Study of In Vivo CAR-T for Treating Advanced Malignant Tumors Based on Target Screening

Inclusion Criteria:

* Age ≥ 18 years.
* Histologically confirmed advanced hematological malignancies (e.g., multiple myeloma, lymphoma) or solid tumors (e.g., small cell lung cancer) that are relapsed or refractory.
* Tumor cells express the relevant target (e.g., BCMA, GPRC5D, DLL3) as required for the specific cohort.
* ECOG performance status 0-2 (hematological malignancies) or 0-1 (solid tumors) and life expectancy ≥ 3 months.
* Adequate organ function (e.g., creatinine clearance ≥45 mL/min, LVEF ≥45%).
* Patients of childbearing potential must agree to use effective contraception during the study and for 1 year after dosing.
* Signed informed consent form.

Exclusion Criteria:

* Active, uncontrolled infection.
* Active central nervous system metastases or involvement.
* Prior anticancer therapy, radiotherapy, or investigational therapy within specified timeframes before the first study dose.
* Severe cardiac or pulmonary disease (e.g., NYHA Class III/IV heart failure), severe hepatic or renal impairment.
* Active Hepatitis B, Hepatitis C, HIV, or syphilis infection.
* Prior allogeneic hematopoietic stem cell transplantation (within specified window) or active graft-versus-host disease.
* Pregnancy or lactation.
* History of severe allergy to any components of the investigational product.
* Any other condition deemed by the investigator to increase risk or interfere with study results.