Clinical trial · Observational
Longitudinal Oral Health Changes After Head and Neck Radiotherapy
Longitudinal Effects of Head and Neck Radiotherapy on Periodontal and Dental Oral Health: A Prospective Cohort Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This prospective observational study evaluates how head and neck radiotherapy affects oral health over time. Patients with head and neck cancer undergoing standard radiotherapy are followed from before treatment through multiple post-treatment visits. Changes in periodontal health, dental status, salivary function, and patient-reported oral health quality of life are assessed. The study aims to better understand the long-term oral complications of radiotherapy and to support improved preventive and supportive dental care for cancer patients.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Head & Neck Cancer | — | UNRESOLVED | — |
| Head & Neck Squamous Cell Carcinoma | — | UNRESOLVED | — |
| Periodontal Disease | — | UNRESOLVED | — |
| Xerostomia | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (1)
- label
- Head and Neck Radiotherapy Cohort
- description
- Adult patients with head and neck cancer undergoing standard external beam radiotherapy who are followed longitudinally to evaluate periodontal health, dental outcomes, salivary function, and oral health-related quality of life.
Primary outcomes (1)
- measure
- Change in Clinical Attachment Level (CAL)
- timeFrame
- Baseline, end of radiotherapy, and 3, 6, 9, and 12 months post-radiotherapy
- description
- Mean change in clinical attachment level measured in millimeters using a standardized UNC-15 periodontal probe at six sites per tooth. CAL is used as the primary indicator of periodontal tissue loss following radiotherapy.
Secondary outcomes (6)
- measure
- Change in Probing Pocket Depth (PPD)
- timeFrame
- Baseline, end of radiotherapy, and 3, 6, 9, and 12 months post-radiotherapy
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age ≥18 years * Histologically confirmed head and neck malignancy * Planned radiotherapy dose ≥50 Gy * Presence of at least 20 natural teeth * No periodontal treatment during the preceding 6 months * Ability to comply with the scheduled follow-up visits Exclusion Criteria: * Previous head and neck radiotherapy * Autoimmune salivary gland disorders * Current bisphosphonate or anti-resorptive therapy * Pregnancy * Uncontrolled systemic disease (HbA1c \>9% for diabetic patients) * Severe periodontal destruction requiring immediate surgical intervention
References
Publications (0)
Data not yet available