Clinical trial · Interventional
Comparison of IVF Outcomes Between PPOS and Antagonist Protocols in Women With PCOS
A Comparative Study of In Vitro Fertilization Outcomes Between PPOS and Antagonist Protocols in Women With Polycystic Ovary Syndrome
NCT07394530CI-TRIAL-00120668PPOS-PCOS-IVFrecruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study aims to compare the outcomes of two ovarian stimulation protocols used in in vitro fertilization (IVF): the progestin-primed ovarian stimulation (PPOS) protocol and the GnRH antagonist protocol.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Female Infertility | — | UNRESOLVED | — |
| Polycystic Ovary Syndrome (PCOS) | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| GnRH Antagonist Protocol | Drug | — | UNRESOLVED |
| Progestin-Primed Ovarian Stimulation (PPOS) | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- PPOS Protocol
- description
- Participants receive ovarian stimulation using the progestin-primed ovarian stimulation (PPOS) protocol for in vitro fertilization.
- interventionNames
- Drug: Progestin-Primed Ovarian Stimulation (PPOS)
- type
- ACTIVE_COMPARATOR
- label
- GnRH Antagonist Protocol
- description
- Participants receive ovarian stimulation using a GnRH antagonist protocol for in vitro fertilization.
- interventionNames
- Drug: GnRH Antagonist Protocol
Primary outcomes (1)
- measure
- Ongoing pregnancy rate at 12 weeks
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 40 Years
Show eligibility criteria text
Inclusion Criteria: * Women aged 18-40 years * Diagnosed with polycystic ovary syndrome (PCOS) according to the modified Rotterdam criteria (2004) (≥2 of 3: oligo/anovulation, hyperandrogenism, or polycystic ovarian morphology on ultrasound) * Indicated for in vitro fertilization (IVF) due to PCOS alone or PCOS with other infertility factors (e.g., tubal factor, previous failed IUI) * Eligible for controlled ovarian stimulation for IVF * Husband/partner with normal sperm parameters or mild to moderate oligoasthenoteratozoospermia (OAT) * Willing and able to provide written informed consent and comply with study procedures. Exclusion Criteria: * Uterine abnormalities that may impair implantation or pregnancy outcomes, including congenital uterine malformations, large fibroids distorting the uterine cavity, adenomyosis, or severe intrauterine pathology. * History of major ovarian or uterine surgery affecting ovarian reserve or uterine structure (e.g., ovarian cystectomy, endometriosis surgery, myomectomy, unilateral oophorectomy) * History of recurrent pregnancy loss (≥3 spontaneous miscarriages) * Known chromosomal abnormalities in either partner * Inability to adhere to study protocol or follow-up procedures
References
Publications (0)
Data not yet available
No reference posted for this study.