Clinical trial · Observational
Surgical Handling of Fertility-preserving Treatments for Cervical Adenocarcinomas
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Despite a growing body of literature on the subject, there is still uncertainty regarding direct comparisons between different conservative surgical techniques for cervical adenocarcinomas. In particular, it remains unclear whether fertility-sparing surgery for cervical adenocarcinomas - characterized by skip lesions - can ensure optimal disease control while achieving adequate obstetric outcomes. For this reason, a systematic review and meta-analysis of the literature, along with an analysis of our center's data, is warranted. This approach will allow a critical, comparative evaluation of the efficacy of the different techniques (conization, simple trachelectomy, and radical trachelectomy) and the identification of prognostic factors to guide therapeutic choice.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cervical Adenosarcoma | Cervical Adenosarcoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (3)
- measure
- Recurrence rate
- timeFrame
- 5 years
- description
- The recurrence rate is defined as the proportion of patients who develop disease recurrence confirmed by imaging or histopathologic evaluation after FSS.
- measure
- Disease free survival
- timeFrame
- 5 years
- description
- Disease-free survival is defined as the time from surgery until the first documented recurrence.
- measure
- Overall survival
- timeFrame
- 5 years
- description
- Overall survival is measured as the time from surgery to death from any cause,
Secondary outcomes (2)
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adult women of reproductive age with a diagnosis of cervical adenocarcinoma * Undergoing fertility-sparing surgery * Minimum 12-month follow-up * Signed informed consent Exclusion Criteria: * Histotypes other than cervical adenocarcinoma * Undergoing radical surgery * Follow-up less than 12 months
References
Publications (0)
Data not yet available