Clinical trial · Observational
Carotid Doppler Parameters and Post-Induction Hypotension
Evaluation of Carotid Doppler Ultrasonography Parameters for Predicting Post-Induction Hypotension in Patients Undergoing Gynecologic Oncology Surgery: A Prospective Observational Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Post-induction hypotension is a common complication following the induction of general anesthesia and is associated with adverse postoperative outcomes. Patients undergoing gynecologic oncology surgery represent a particularly vulnerable population due to advanced age, high comorbidity burden, and increased frailty, which may predispose them to perioperative hemodynamic instability. This prospective observational study aims to evaluate whether carotid Doppler ultrasonography parameters, including corrected flow time and other flow-related indices, can predict the occurrence of post-induction hypotension specifically in patients undergoing gynecologic oncology surgery. Adult patients scheduled for elective gynecologic oncology surgery under general anesthesia will undergo pre-induction carotid Doppler ultrasonography as part of routine perioperative assessment. Baseline clinical characteristics, including the Charlson Comorbidity Index and Clinical Frailty Scale, will be recorded for each participant. Hemodynamic parameters will be recorded following anesthetic induction, and the development of post-induction hypotension will be assessed. The findings of this study may help identify high-risk patients within the gynecologic oncology population and support the use of non-invasive carotid Doppler measurements, comorbidity burden, and frailty assessment for perioperative risk stratification in this specific surgical group.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gynecologic Oncology Patient | — | UNRESOLVED | — |
| Post-induction Hypotension (PIH) | — | UNRESOLVED | — |
| Ultrasonography, Doppler | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| pre- induction carotid doppler ultrasonography | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Gynecologic Oncology Surgery Cohort
- description
- Prospective observational single-center cohort of adult patients undergoing elective gynecologic oncology surgery under general anesthesia. Pre-induction carotid Doppler ultrasonography parameters were recorded to evaluate the prediction of post-induction hypotension. Baseline comorbidity burden and frailty status were assessed using the Charlson Comorbidity Index and Clinical Frailty Scale. No study-specific interventions were performed.
- interventionNames
- Other: pre- induction carotid doppler ultrasonography
Primary outcomes (1)
- measure
- Occurrence of Post-Induction Hypotension
- timeFrame
- Within the first 20 minutes after induction of general anesthesia
- description
- Post-induction hypotension defined as a mean arterial pressure \<65 mmHg within the early post-induction period following induction of general anesthesia.
Secondary outcomes (5)
- measure
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Female patients aged 18 years or older * Scheduled for elective gynecologic oncology surgery under general anesthesia * Planned standard anesthetic induction * Ability to provide written informed consent Exclusion Criteria: * Refusal to participate in the study * Inability to obtain informed consent, including patients with dementia * Emergency surgery * American Society of Anesthesiologists (ASA) physical status IV or higher * Cardiac rhythm other than sinus rhythm * Autonomic nervous system disorders * Atrial fibrillation with rapid ventricular response * Pregnancy * Sepsis or septic shock * Significant valvular heart disease or peripheral vascular disease * Anticipated difficult ventilation and/or difficult intubation * Left ventricular ejection fraction \<40% * Severe aortic valve stenosis * Morbid obesity (body mass index \>40 kg/m²) * Presence of implanted cardiac pacemaker or implantable cardioverter-defibrillator * Chronic beta-blocker therapy * Baseline mean arterial pressure \<65 mmHg at admission * Baseline systolic arterial blood pressure \>190 mmHg or diastolic arterial blood pressure \>110 mmHg
References
Publications (0)
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