Clinical trial · Interventional
Questionnaire on Congenital Cancer Signs Through Self-Assessment
Questionnaire on Congenital Cancer Signs Through Self-Assessment (QUOCCAS)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This clinical trial tests whether a patient- and caregiver-completed questionnaire (QUOCCAS) can accurately help identify children and adolescents with cancer who may have an underlying cancer predisposition syndrome (CPS). The study will also evaluate whether providing families with an educational brochure before their clinic visit improves their understanding of genetics and their satisfaction with care. The main questions it aims to answer are: * Does QUOCCAS identify children at risk for CPS as accurately as physician-based tools and compared to genetic testing? * Does the Pre-Visit Preparation (PVP) brochure improve caregiver knowledge about genetics? * Does the PVP brochure improve caregiver satisfaction with the care and information they receive? Participants will: * Complete the QUOCCAS questionnaire about family history, clinical features, and cancer signs * Provide a blood or saliva sample for genetic testing (whole-exome or whole-genome sequencing) * Randomly receive or not receive the educational Pre-Visit Preparation brochure before completing the questionnaire * Complete brief surveys on their knowledge and satisfaction
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer Predisposition Syndromes | — | UNRESOLVED | — |
| Childhood Neoplasms | Childhood Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Hereditary Cancer Syndromes | — | UNRESOLVED | — |
| Pediatric Cancer | Childhood Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Germline genetic sequencing for Cancer Predisposition Syndromes (CPS) | Diagnostic Test | — | UNRESOLVED |
| MIPOGG Assessment | Diagnostic Test | — | UNRESOLVED |
| Pre-Visit Preparation (PVP) Brochure | Behavioral | — | UNRESOLVED |
| QUOCCAS Questionnaire | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Pre-Visit Preparation (PVP) Brochure + QUOCCAS Questionnaire
- description
- Participants will receive the educational Pre-Visit Preparation (PVP) brochure before completing the QUOCCAS questionnaire. They will also provide a saliva or blood sample for germline genetic sequencing and complete follow-up surveys.
- interventionNames
- Behavioral: Pre-Visit Preparation (PVP) Brochure
- Diagnostic Test: QUOCCAS Questionnaire
- Diagnostic Test: Germline genetic sequencing for Cancer Predisposition Syndromes (CPS)
- Diagnostic Test: MIPOGG Assessment
- type
- ACTIVE_COMPARATOR
- label
- QUOCCAS Questionnaire Only
- description
- Participants will complete the QUOCCAS questionnaire without receiving the Pre-Visit Preparation (PVP) brochure. They will also provide a saliva or blood sample for germline genetic sequencing and complete follow-up surveys.
- interventionNames
- Diagnostic Test: QUOCCAS Questionnaire
Eligibility
Eligibility (as posted)
- Sex
- All
- Maximum age
- 21 Years
Show eligibility criteria text
Inclusion Criteria: * The investigators will include newly diagnosed patients who received a cancer diagnosis included in the International Classification of Childhood Cancer version 3 (ICCC3) criteria, treated at participating hospitals Exclusion Criteria: * Over 21 years of age
References
Publications (0)
Data not yet available