Clinical trial · Interventional
Aerobic Exercise vs Physiological Ischemic Training in Stage 2 Hypertension
The Effect of Aerobic Exercise and Physiological Ischemic Training on VEGF, Interleukin-6, Interleukin-10, Cardiorespiratory Fitness, Muscle Strength, and Quality of Life in Patients With Hypertension
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study aims to compare the effects of aerobic exercise (AE) and physiological ischemic training (PIT) on inflammatory and angiogenesis biomarkers (VEGF, IL-6, IL-10), cardiorespiratory fitness, muscle strength, and quality of life in patients with grade 2 primary hypertension (HT2). This randomized controlled trial will involve 60 HT2 patients from Pratama and Utama Medika Antapani Clinic, who will be assigned to either AE or PIT groups. The intervention will last 6 weeks, and outcomes measured will include biomarker levels, VO2max, 6-minute walk distance (6-MWD), maximum voluntary contraction (MVC), and SF-36 questionnaire scores.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Primary Hypertension, Grade 2 | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Aerobic Exercise (AE) | Behavioral | — | UNRESOLVED |
| Physiological Ischemic Training (PIT) | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Aerobic Exercise (AE)
- description
- Participants will perform a structured aerobic exercise program for 6 weeks, supervised by trained personnel. Outcomes measured include biomarkers (VEGF, IL-6, IL-10), cardiorespiratory fitness (VO2max, 6-minute walk distance), muscle strength (MVC), and quality of life (SF-36).
- interventionNames
- Behavioral: Aerobic Exercise (AE)
- type
- EXPERIMENTAL
- label
- Physiological Ischemic Training (PIT)
- description
- articipants will perform a 6-week physiological ischemic training program, supervised by trained personnel. Outcomes measured include biomarkers (VEGF, IL-6, IL-10), cardiorespiratory fitness (VO2max, 6-minute walk distance), muscle strength (MVC), and quality of life (SF-36).
- interventionNames
- Behavioral: Physiological Ischemic Training (PIT)
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: 1. Primary hypertension patients aged 18-65 years 2. Diagnosed with grade 2 primary hypertension 3. Willing to participate in the study Exclusion Criteria: 1. Patients with unstable angina 2. Malignant arrhythmias and high atrioventricular block 3. Unstable hemodynamics 4. Uncontrolled hypertension 5. Acute pericarditis 6. Severe valvular heart disease 7. Chronic obstructive pulmonary disease 8. Cor pulmonale and pulmonary vascular disease 9. Thrombophlebitis 10. Intermittent claudication 11. Cognitive impairment 12. Uncooperative subjects 13. Subjects experiencing infection or inflammation 14. Subjects with neuromuscular disorders that may affect the study results 15. Subjects with musculoskeletal disorders that may affect the study results 16. Complications or comorbidities such as cerebrovascular disease, CAD, atheroma plaques on imaging, heart failure, PAD, and atrial fibrillation.
References
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