Clinical trial · Interventional
Thermal Artifact in Patients Undergoing Conization: A Clinical Study
Comparison of the Effects of Different Surgical Techniques on the Degree of Thermal Artifact in Patients Undergoing Conization: A Clinical Study
NCT07372248CI-TRIAL-00104362recruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Cervical transformation zone excision is commonly used in the diagnosis and treatment of cervical intraepithelial neoplasia. Thermal artifacts can negatively affect histopathological evaluation. This study compares three different modifications of conization performed using electrosurgery in terms of the degree of thermal artifacts.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cervix, Dysplasia | Cervical Intraepithelial Neoplasia | ALIAS | 0.90 |
| Cervix Neoplasm | Cervical Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Conization with Electrosurgery diffferent power settings | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- Pure Cut
- description
- Conization with Electrosurgery: Power Setting 50 watts pure cut
- interventionNames
- Procedure: Conization with Electrosurgery diffferent power settings
- type
- ACTIVE_COMPARATOR
- label
- Blend
- description
- Conization with Electrosurgery:Power Setting 50 watts blend
- interventionNames
- Procedure: Conization with Electrosurgery diffferent power settings
- type
- EXPERIMENTAL
- label
- Hybrid
- description
- Conization with Electrosurgery and Knife: Power Setting 50 watts pure cut and knife
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria:Women aged ≥18 years Indication for LLETZ based on abnormal cervical cytology and/or biopsy Ability to provide written informed consent - Exclusion Criteria: Previous cervical excisional procedure Pregnancy Active cervical infection History of cervical cancer \-
References
Publications (3)
- BACKGROUNDPrendiville W, Cullimore J, Norman S. Large loop excision of the transformation zone (LLETZ). A new method of management for women with cervical intraepithelial neoplasia. Br J Obstet Gynaecol. 1989 Sep;96(9):1054-60. doi: 10.1111/j.1471-0528.1989.tb03380.x. PMID 2804007
- BACKGROUNDWatanabe Y, Fuchshuber P, Homma T, Bilgic E, Madani A, Hiki N, Cammack I, Noji T, Kurashima Y, Shichinohe T, Hirano S. An Unmodulated Very-Low-Voltage Electrosurgical Technology Creates Predictable and Ultimate Tissue Coagulation: From Experimental Data to Clinical Use. Surg Innov. 2020 Oct;27(5):492-498. doi: 10.1177/1553350620904610. Epub 2020 Mar 18. PMID 32186463
- BACKGROUNDNagar HA, Dobbs SP, McClelland HR, Price JH, McClean G, McCluggage WG. The large loop excision of the transformation zone cut or blend thermal artefact study: a randomized controlled trial. Int J Gynecol Cancer. 2004 Nov-Dec;14(6):1108-11. doi: 10.1111/j.1048-891X.2004.14608.x. PMID 15571616