Clinical trial · Interventional
Effects and Safety of Oliceridine in Anesthesia Induction:A Randomised Controlled Trial
Study of Effects and Underlying Mechanisms of Analgesic Drugs on Inflammatory Pathways and Immune Function in Patients With Endometrial Cancer
NCT07372209CI-TRIAL-00101881completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
to investigate whether oliceridine is safe and effective for induction of anesthesia by comparing henodynamic changes before and after endotracheal intubation with sufentanil
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| General Anesthetic | — | UNRESOLVED | — |
| Gynecological Laparoscopic Surgery | — | UNRESOLVED | — |
| Intubation | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Oliceridine | Drug | — | UNRESOLVED |
| Sufentanil | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- sufentanil
- description
- 0.5μg/kg of sufentanil was used for anesthesia induction
- interventionNames
- Drug: Sufentanil
- type
- EXPERIMENTAL
- label
- Oliceridine
- description
- 0.13mg/kg oliceridine was used for anesthesia induction
- interventionNames
- Drug: Oliceridine
Primary outcomes (2)
- measure
- blood pressure
- timeFrame
- baseline, at the moment of intubation, right after intubation, 1 minute、3 minutes, and 5 minutes after intubation
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: 1. Age 18-65 years; 2. American Society of Anesthesiologists (ASA) physical status I-II; 3. Elective gynecologic laparoscopic surgery; 4. Expected operative time 60-180 minutes; Exclusion Criteria: 1. Severe cardiovascular instability (e.g., acute decompensated heart failure, acute myocardial infarction, or life-threatening arrhythmia); 2. Uncontrolled hypertension; 3. Severe renal or hepatic dysfunction; 4. Severe mental disorder or psychiatric illness; 5. Known allergy or hypersensitivity to opioids; 6. History of alcohol abuse or opioid addiction; 7. Anticipated difficult airway; 8. Pregnancy or lactation;
References
Publications (6)
- BACKGROUNDSimons P, van der Schrier R, van Lemmen M, Jansen S, Kuijpers KWK, van Velzen M, Sarton E, Nicklas T, Michalsky C, Demitrack MA, Fossler M, Olofsen E, Niesters M, Dahan A. Respiratory Effects of Biased Ligand Oliceridine in Older Volunteers: A Pharmacokinetic-Pharmacodynamic Comparison with Morphine. Anesthesiology. 2023 Mar 1;138(3):249-263. doi: 10.1097/ALN.0000000000004473. PMID 36538359
- BACKGROUNDStahl EL, Schmid CL, Acevedo-Canabal A, Read C, Grim TW, Kennedy NM, Bannister TD, Bohn LM. G protein signaling-biased mu opioid receptor agonists that produce sustained G protein activation are noncompetitive agonists. Proc Natl Acad Sci U S A. 2021 Nov 30;118(48):e2102178118. doi: 10.1073/pnas.2102178118. PMID 34819362
- BACKGROUNDYang W, Zhou R, Zhou X, Chen X, Zhou D, Zhang X. Effective Dose of Oliceridine Fumarate Co-Administered with Remimazolam in Suppressing Gastroscope Insertion Responses for Adults. Drug Des Devel Ther. 2025 Jun 10;19:5033-5041. doi: 10.2147/DDDT.S527586. eCollection 2025. PMID 40524805
- BACKGROUNDMa B, Li Y, Leng C, Ji A, Zhang N, Tao X, Cao Q, Wang S. A Comparative Evaluation of the Safety and Efficacy of Oliceridine and Sufentanil in Gastrointestinal Endoscopy: A Single-Center, Randomized Controlled Trial. Drug Des Devel Ther. 2025 Jun 17;19:5111-5121. doi: 10.2147/DDDT.S512529. eCollection 2025. PMID 40546662
- BACKGROUNDIannuzzi E, Iannuzzi M, Cirillo V, Viola G, Parisi R, Cerulli A, Chiefari M. Peri-intubation cardiovascular response during low dose remifentanil or sufentanil administration in association with propofol TCI. A double blind comparison. Minerva Anestesiol. 2004 Mar;70(3):109-15. PMID 14997083
- BACKGROUNDTeong CY, Huang CC, Sun FJ. The Haemodynamic Response to Endotracheal Intubation at Different Time of Fentanyl Given During Induction: A Randomised Controlled Trial. Sci Rep. 2020 Jun 1;10(1):8829. doi: 10.1038/s41598-020-65711-9.