Clinical trial · Observational
Clinical Management Strategies for Patients With Cirrhosis and Esophagogastric Varices Complicated by Early-stage Upper Gastrointestinal Cancer
Clinical Management Strategies for Patients With Cirrhosis and Esophagogastric Varices Complicated by Early-stage Upper Gastrointestinal Cancer: a Multicenter Retrospective Cohort Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Managing early-stage upper gastrointestinal cancer in patients with liver cirrhosis and esophagogastric varices (EGV) poses substantial clinical challenges. Although endoscopic submucosal dissection (ESD) is an established treatment for these early cancers, its efficacy and safety in this high-risk population are poorly defined. Therefore, this study aims to investigate optimal screening and treatment strategies for early-stage upper gastrointestinal cancer in cirrhotic patients with EGV. Perioperative outcomes were compared between the two groups.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cirrhosis | — | UNRESOLVED | — |
| Early-stage Upper Gastrointestinal Cancer | — | UNRESOLVED | — |
| Esophagogastric Varices | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- cirrhosis group
- description
- cirrhotic patients with EGV and early-stage upper gastrointestinal cancer 问who underwent ESD
- label
- noncirrhosis group
- description
- Patients who underwent ESD without cirrhosis and EGV
Primary outcomes (6)
- measure
- Mortality
- timeFrame
- Perioperative
- description
- Patients who died due to ESD
- measure
- ICU transfer
- timeFrame
- Perioperative
- description
- Transferred to ICU due to ESD
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: The cirrhosis group: * Age \>18 years; * A clinical diagnosis of liver cirrhosis * Endoscopically confirmed EGV. The noncirrhosis group: * Age \> 18 years * With early-stage upper gastrointestinal cancer but without cirrhosis Exclusion Criteria: * Concomitant end-stage disease of major organs (e.g., active malignancy, heart failure, respiratory failure) or an American Society of Anesthesiologists (ASA) physical status classification ≥ III * Previous surgery for cirrhosis, EGV, or other upper gastrointestinal lesions * Incomplete clinical records.
References
Publications (0)
Data not yet available