Clinical trial · Observational
Coronary Computed Tomography Angiography In Rheumatoid Arthritis Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The Coronary Computed Tomography Angiography in Rheumatoid Arthritis study is part of the multinational, prospective, observational Autoimmunity and Atherosclerosis in Rheumatic Diseases cohort (https://atacc-rd.com) that includes comprehensive baseline and follow-up assessments at 3, 5, and 10 years. It comprises a main protocol and several optional modules, including a Cardiac Imaging Module, Biobanking Module, Pulmonary Module, and Anxiety and Depression Module. The study aims to advance understanding of cardiopulmonary and psychological comorbidities in rheumatoid arthritis, to improve early identification and management, and to enhance insights into underlying disease mechanisms-ultimately refining risk stratification and targeted prevention strategies. The study includes 4,000 patients with rheumatoid arthritis enrolled through the Cardiac Imaging Module in the main protocol. Participants undergo coronary computed tomography angiography, pulmonary function testing, physical examination, questionnaires, and biobanking, supplemented by genetic, proteomic, metabolomic, and microbiome profiling.
Conditions
Conditions (17)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anxiety Disorders | — | UNRESOLVED | — |
| Atherosclerotic Ischemic Disease | — | UNRESOLVED | — |
| Cardiovascular and Respiratory Disease | — | UNRESOLVED | — |
| Cardiovascular Biomarkers | — | UNRESOLVED | — |
| Cardiovascular (CV) Risk | — | UNRESOLVED | — |
| Cardiovascular Disease | — | UNRESOLVED | — |
| Cardiovascular Disease (CKD) | — | UNRESOLVED | — |
| Cardiovascular Disease (CVD) Risk Factors | — | UNRESOLVED | — |
| COPD (Chronic Obstructive Pulmonary Disease) | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (3)
- measure
- Number of participants with a first occurrence of Major Adverse Cardiovascular Events (MACE)
- timeFrame
- 3, 5 and 10 years
- description
- 1. Cardiovascular death as defined by death from any of the following causes: Ischemic heart disease; Sudden cardiac death; Ventricular tachycardia; Other cardiac arrhythmias; Heart failure; Fatal ischemic stroke; Sudden undefined death; Unwitnessed or unknown cause of death 2. Hospitalization for non-fatal myocardial infarction, including hospitalization for PCI and CABG 3. Hospitalization for non-fatal ischemic stroke
- measure
- Number of participants with a first occurrence of any ischemic cardiovascular events, including MACE
- timeFrame
- 3, 5 and 10 years
- description
- Hospitalization for cerebrovascular disease (transient ischemic attack). Hospitalization for peripheral vascular disease. Hospitalization for peripheral vascular surgery. Cardiovascular death as defined by death from any of the following causes: Ischemic heart disease; Sudden cardiac death; Ventricular tachycardia; Other cardiac arrhythmias; Heart failure; Fatal ischemic stroke; Sudden undefined death; Unwitnessed or unknown cause of death. Hospitalization for non-fatal myocardial infarction, including hospitalization for PCI and CABG. Hospitalization for non-fatal ischemic stroke
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 50 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Fulfill the ACR/EULAR-2010 criteria for rheumatoid arthritis * Attending or has attended at least one visit during the last two years in rheumatology outpatient clinic for diagnostic or monitoring purposes related to rheumatoid arthritis * Age 50-75 years Exclusion Criteria: * Diagnosed with overlapping systemic autoimmune diseases other than secondary Sjogren's syndrome * Active cancer * Prior coronary atherosclerotic symptoms as defined by myocardial infraction, percutaneous coronary intervention, or coronary artery bypass grafting * Allergy to radiocontrast agents * Estimated glomerular filtration rate (eGFR) \< 30 mL/min * BMI \> 35 kg/m2 * Persistent atrial fibrillation
References
Publications (0)
Data not yet available