Clinical trial · Interventional
Thyroid Artery Embolization for the Treatment of Compressive Goiters.
Thyroid Artery Embolization for the Treatment of Compressive Goiters: a Prospective Cohort Study.
NCT07360587CI-TRIAL-00101380TAErecruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Very few studies have investigated TAE as a treatment for goiter with compressive symptoms. What is the efficacy and safety of TAE for the treatment of compressive goiters in a population ineligible for or refusing standard therapy? This is a prospective interventional cohort study that will allow us to standardize imaging by improving quality data collection and fellow-up to assess the efficacy of TAE for compressive symptoms of nodular goiters. Not only to corroborate current emerging results but clearly define the expected results for this technique.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Thyroid Nodules | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Thyroid Artery Embolization | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Thyroid Artery Embolization
- description
- Patients with diagnosis of Goiter with compressive symptoms in which other alternatives lack or are refused by the patient himself.
- interventionNames
- Procedure: Thyroid Artery Embolization
Primary outcomes (1)
- measure
- Change in Thyroid nodule volume
- timeFrame
- Follow-ups at 1 week, and 3 months, 6 months and 12 months post-op.
- description
- TAE effectiveness to reduce overall thyroid and nodular volumes in benign compressive goiters assessing changes in Nodule(s) volume(s) and Thyroid lobe volume.
Secondary outcomes (4)
- measure
- Change in symptoms after TAE.
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patient with compressive symptoms or significant tracheal or oesophageal compression at risk of causing symptoms attributed to a goiter AND * Ineligible for surgery/ablative treatments or preference for TAE over other treatments AND * TiRADS category 1, 2, 3 or 4 AND * Bethesda categories I or III on 2 different biopsies OR Bethesda II on one biopsy AND * Patient at least 18 years old. Exclusion Criteria: * Comorbidities precluding endovascular procedure OR * TiRADS category 5 OR * Bethesda categories IV, V, VI on biopsy OR * Refusal of the patient to participate OR * Uncontrolled severe hyperthyroidism OR * Minor patient.
References
Publications (11)
- BACKGROUNDRamos HE, Braga-Basaria M, Haquin C, Mesa CO, Noronha Ld, Sandrini R, Carvalho Gde A, Graf H. Preoperative embolization of thyroid arteries in a patient with large multinodular goiter and papillary carcinoma. Thyroid. 2004 Nov;14(11):967-70. doi: 10.1089/thy.2004.14.967. PMID 15671777
- BACKGROUNDBonnici M, Nevin C, Boo S. Thyroid ima artery embolization for the treatment of Graves' disease and thyroid storm. Radiol Case Rep. 2023 May 28;18(8):2641-2644. doi: 10.1016/j.radcr.2023.04.044. eCollection 2023 Aug. PMID 37273723
- BACKGROUNDXiao H, Zhuang W, Wang S, Yu B, Chen G, Zhou M, Wong NC. Arterial embolization: a novel approach to thyroid ablative therapy for Graves' disease. J Clin Endocrinol Metab. 2002 Aug;87(8):3583-9. doi: 10.1210/jcem.87.8.8723. PMID 12161479
- BACKGROUNDGalkin EV, Grakov BS, Protopopov AV. [First clinical experience of radio-endovascular functional thyroidectomy in the treatment of diffuse toxic goiter]. Vestn Rentgenol Radiol. 1994 May-Jun;(3):29-35. Russian. PMID 7985368
- BACKGROUNDMcDermott MT. Hyperthyroidism. Ann Intern Med. 2020 Apr 7;172(7):ITC49-ITC64. doi: 10.7326/AITC202004070. PMID 32252086
- BACKGROUNDLim HK, Lee JH, Ha EJ, Sung JY, Kim JK, Baek JH. Radiofrequency ablation of benign non-functioning thyroid nodules: 4-year follow-up results for 111 patients. Eur Radiol. 2013 Apr;23(4):1044-9. doi: 10.1007/s00330-012-2671-3. Epub 2012 Oct 25. PMID 23096937
- BACKGROUNDGuan SH, Wang H, Teng DK. Comparison of ultrasound-guided thermal ablation and conventional thyroidectomy for benign thyroid nodules: a systematic review and meta-analysis. Int J Hyperthermia. 2020;37(1):442-449. doi: 10.1080/02656736.2020.1758802. PMID 32369708