Clinical trial · Interventional
Nanocrystalline Megestrol Acetate for Cachectic Stage Locally Advanced Hepatocellular Carcinoma
A Prospective Clinical Study of Nanocrystalline Megestrol Acetate in Combination With Standard Therapy Versus Standard Therapy Alone for Cachectic Stage Locally Advanced Hepatocellular Carcinoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study is a prospective, randomized, parallel-controlled clinical trial. The primary objective is to evaluate the superiority and safety of nanocrystalline megestrol acetate in combination with standard therapy compared with standard therapy alone in improving appetite and body mass index (BMI) during treatment in patients with early-stage or locally advanced hepatocellular carcinoma at the cachexia stage.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cachexia | — | UNRESOLVED | — |
| Hepatocellular Carcinoma | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Nanocrystalline Megestrol Acetate | Drug | — | UNRESOLVED |
| Standard Antitumor Therapy | Combination Product | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Nanocrystalline Megestrol Acetate Oral Suspension + Standard Antitumor Therapy
- description
- Nanocrystalline Megestrol Acetate Oral Suspension + Standard Antitumor Therapy
- interventionNames
- Drug: Nanocrystalline Megestrol Acetate
- Combination Product: Standard Antitumor Therapy
- type
- ACTIVE_COMPARATOR
- label
- Standard Antitumor Therapy
- description
- Standard Antitumor Therapy
- interventionNames
- Combination Product: Standard Antitumor Therapy
Primary outcomes (1)
- measure
- The proportion of subjects with improved appetite based on A/CS-12 assessment.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 85 Years
Show eligibility criteria text
Inclusion Criteria: 1. Patients with hepatocellular carcinoma who have not previously received systemic therapy and are confirmed by histological or cytological assessment, as evaluated by the investigator, to be unsuitable or ineligible for curative surgical resection; Barcelona Clinic Liver Cancer (BCLC) stage B-C. 2. Child-Pugh class A or B7. 3. Planned to receive interventional therapy in combination with systemic antitumor therapy. 4. At least one measurable tumor lesion according to mRECIST v1.1. 5. Meet the diagnostic criteria for pre-cachexia or cachexia (based on the Fearon criteria). Exclusion Criteria: 1. Presence of any condition affecting gastrointestinal absorption, such as dysphagia, malabsorption, or uncontrolled vomiting; patients receiving tube feeding or parenteral nutrition. 2. Presence of anorexia due to anorexia nervosa, psychiatric disorders, or pain that makes eating difficult. 3. Patients with acquired immunodeficiency syndrome (AIDS). 4. Currently receiving or planning to receive other medications that increase appetite or body weight, such as corticosteroids (except short-term dexamethasone during chemotherapy), androgens, progestins, thalidomide, olanzapine, anamorelin, or other appetite stimulants. 5. Patients with Cushing's syndrome, adrenal or pituitary insufficiency, or poorly controlled diabetes mellitus.
References
Publications (0)
Data not yet available