Clinical trial · Observational
Impact of Molecular Pathological And Clinical Features for Adjuvant Treatment Selection in Endometrial Cancer: Asian Registry
Impact of Molecular Pathological And Clinical Features for Adjuvant Treatment Selection in Endometrial Cancer: Multicentric Asian Registry (IMPACT-Endo-Asia)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The treatment practices for endometrial cancer have significantly changed over the last two decades. Nowadays, in addition to standard pathology, additional tests are performed to understand the behaviour of tumour so that personalized treatment can be advised for every patient. This approach ensures that patients with good cancer cell features receive minimum essential radiotherapy or surgery treatment with fewer side effects, while those with poor cell features undergo more aggressive treatment to improve their chances of survival. However, this approach is not widely adopted in Asian countries. To address this, investigators are launching a project to gather data from various hospitals across Asia. The project aims to understand how different cancer cell factors impact treatment decisions and identify better ways to select additional treatment plans based on a patient's cancer cell features. The project will gather data from around 250-300 patients who were evaluated or treated between January 2021 and December 2023. It will run for two years to improve our understanding and gain insights into the best ways to treat endometrial cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Endometrial Cancer | Malignant Endometrial Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (4)
- measure
- To study the Clinico-pathological characteristics in Endometrial Cancer
- timeFrame
- 24 months
- description
- Proportion of Endometrial Cancer Molecular Subtypes (POLEmut, MMR-deficient, NSMP, p53 abnormal) and distribution of adjuvant radiation therapy types received (vaginal brachytherapy, external beam radiation therapy \[EBRT\], or combined radiation with chemotherapy) reported at treatment completion.
- measure
- To study molecular characteristics in Endometrial Cancer.
- timeFrame
- 24 Months
- description
- Proportion of Endometrial Cancer Cases by Tumor Grade, Histological Type, and Tumor Stage
- measure
- To study the Clinicopathologic characteristics impact on treatment decision making across Asian regions
- timeFrame
- 24 Months
- description
- proportion of patients who exhibit predefined clinicopathologic characteristics with percentages reported for each participating Asian region
Eligibility
Eligibility (as posted)
- Sex
- Female
Show eligibility criteria text
Inclusion Criteria: \- Patients who were diagnosed to have EC and have access to standard histopathological reports and availability of treatment decisions. Exclusion Criteria: \- Patients with final histopathological diagnosis of any other gynecological malignancy other than EC and its subtypes.
References
Publications (0)
Data not yet available