Clinical trial · Observational

Long-term Outcomes and Risk Factors of Local Re-Recurrence in Patients

Long-term Outcomes and Risk Factors of Local Re-Recurrence in Patients With Locally Recurrent Rectal Cancer

NCT07353567CI-TRIAL-00104404completedClinicalTrials.gov clinicaltrialsPublishedExplore in graph →

Summary

Brief summary (as posted)

To analyze the long-term oncological outcome and identify independent risk factors for local re-recurrence in patients undergoing radical salvage surgery for locally recurrent rectal cancer.

Conditions

Conditions (2)

Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.

Condition (as posted)	Mapped entity	Match	Confidence
Local Recurrence of Malignant Tumor of Rectum	—	UNRESOLVED	—
Local Re-Recurrence of Malignant Tumor of Rectum	—	UNRESOLVED	—

Interventions

Interventions (0)

Data not yet available

No intervention recorded.

Design

Arms and outcomes

Arms (2)

label
patients without local re-recurrence
label
patients with local re-recurrence

Primary outcomes (2)

measure
Local re-recurrence free survival
timeFrame
LrRFS was calculated from the date of salvage radical surgery until the date when any local re-recurrence was detected by imaging or histology, or until censored at the last follow-up or death, assessed up to 180 months.]
measure
post-recurrent overall survival
timeFrame
PROS was calculated from the date of salvage radical surgery until the date of death or until censored at the last follow-up, assessed up to 180 months.

Eligibility

Eligibility (as posted)

Sex: All

Show eligibility criteria text

Inclusion Criteria:

* (1). Patients had undergone curative-intent resection for a histologically confirmed primary rectal or rectosigmoid adenocarcinoma. A disease-free interval ≥1 months was required to distinguish subsequent local recurrence from persistent disease;
* (2). LRRC located within the true pelvis or at the pelvic brim, confirmed by radiological imaging (e.g., MRI, CT, PET-CT) and/or pathological verification;
* (3). Patients who underwent radical salvage surgery (R0/R1) for LRRC. No evidence of residual disease or early second recurrence was observed within 1 months after salvage surgery.
* (4). Availability of complete clinicopathological and treatment-related data.

Exclusion Criteria:

* (1). History of synchronous or metachronous other primary malignancies;
* (2). R2 resection for LRRC;
* (3). Presence of uncontrollable synchronous distant metastasis at the time of either primary tumor treatment or LRRC diagnosis;
* (4). Patients lost to follow-up or lacking essential survival data.

References

Publications (0)

Data not yet available

No reference posted for this study.