Clinical trial · Observational
Postoperative Complications After Neoadjuvant Chemoradiotherapy or Short-course Radiotherapy and Total Neoadjuvant Treatment: a Multicentric Retrospective Cohort Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The primary objective of the study is to compare the rate of postoperative complications between rectal cancer patients undergoing standard neoadjuvant chemoradiotherapy or short- course radiotherapy and patients receiving TNT. The secondary objectives of the study include the evaluation of treatment-related adverse reactions and postoperative complications in elderly patients receiving the treatments and the comparison of treatment-related adverse reactions and postoperative complications in patients receiving induction versus consolidation TNT.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Adult Patients With Locally Advanced Rectal Cancer Indicated to Neoadjuvant Therapy and Surgery | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Chemoradiotherapy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Chemoradiotherapy
- description
- Patient received chemoradiotherapy or short course radiotherapy before surgery
- interventionNames
- Procedure: Chemoradiotherapy
- label
- TNT
- description
- TNT neoadjuvant treatment
- interventionNames
- Procedure: Chemoradiotherapy
Primary outcomes (2)
- measure
- 90 days postoperative complications
- timeFrame
- 12 months
- description
- The primary endpoint of the study is the rate of 90-day postoperative complications between the study cohorts.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with locally advanced (T2N+, T3N+, T4N0, or T4N+) rectal adenocarcinoma who underwent neoadjuvant chemoradiotherapy or short-course radiotherapy or TNT and surgery between January 2016 and January 2025; * Patients who underwent restorative or non-restorative surgery; * Patients undergoing open, laparoscopic, or robotic intervention. Exclusion Criteria: * Patients who underwent non-operative management after neoadjuvant treatment.
References
Publications (0)
Data not yet available