Clinical trial · Observational
Investigation of the Impact of Myomectomy on Uterine Artery Doppler Velocimetry Findings
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Objective: This scientific study aims to investigate whether myomectomy induces significant changes in uterine artery blood flow patterns. While Doppler ultrasonography is traditionally used to assess myoma vascularity, differential diagnosis (adenomyoma or sarcoma), and fertility impacts, there is a lack of prospective evidence comparing preoperative and postoperative uterine artery Doppler findings. Study Design and Rationale: The study will evaluate the hemodynamic influence of myomectomy by comparing flow measurements in the main uterine artery before and after surgical intervention. Existing literature has primarily focused on the correlation between myoma volume and vascular resistance; however, the direct impact of surgical removal of a myoma on uterine artery doppler velocimetry remains under-investigated. Participant Involvement: Participation is entirely voluntary, and participants may withdraw at any time without any impact on their medical care. Data collection involves routine clinical history, physical examination, and non-invasive ultrasound measurements. Clinical Significance: By establishing the effect of myoma removal on uterine blood supply, this research aims to provide guiding data for the follow-up and treatment planning of patients with leiomyomas. The findings may offer new insights into how surgical management restores or alters uterine hemodynamics, potentially influencing future diagnostic and therapeutic approaches.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Doppler Ultrasound | — | UNRESOLVED | — |
| Leiomyoma (Uterine Fibroids) | Leiomyoma | ONTOLOGY_EXACT | 0.85 |
| Myomectomy | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- preoperative doppler measurements
- description
- Uterine leiomyoma cases before myomectomy operation will be investegated measuring doppler indices of pulsatility index, resistance index and systolic/dyastolic ratio.
- label
- postoperative doppler measurements
- description
- Uterine leiomyoma cases who had myomectomy operation will be investegated measuring doppler indices of pulsatility index, resistance index and systolic/dyastolic ratio at the late postoperative period (40 days postoperatively)
Primary outcomes (3)
- measure
- Pulsatility index
- timeFrame
- from the enrollment in preoperative period to the late postoperative period (40 days after operation)
- description
- Pulsatility index will be measured in bilateral uterine arteries preoperatively and postoperatively in myomectomy cases.
- measure
- resistance index
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Premenopausal women aged between 18 and 50 years. * Women with uterine leiomyoma detected via ultrasonography. * Patients referred to the Obstetrics and Gynecology department board for whom a myomectomy operation has been decided. * Women who provide consent for transvaginal ultrasound examination. Exclusion Criteria: * Women under 18 years of age and postmenopausal women. * Current pregnancy or postpartum status. * Presence of known circulatory disorders, cardiovascular diseases, or other chronic conditions affecting blood flow. * Smokers. * Current use of hormonal medications (e.g., oral contraceptives, levonorgestrel-releasing intrauterine devices, etc.). * Presence of concurrent gynecological pathologies (e.g., adenomyosis, endometriosis, ovarian cysts, or gynecological malignancies).
References
Publications (4)
- BACKGROUNDGiuliani E, As-Sanie S, Marsh EE. Epidemiology and management of uterine fibroids. Int J Gynaecol Obstet. 2020 Apr;149(1):3-9. doi: 10.1002/ijgo.13102. Epub 2020 Feb 17. PMID 31960950
- BACKGROUNDCiarmela P, Delli Carpini G, Greco S, Zannotti A, Montik N, Giannella L, Giuliani L, Grelloni C, Panfoli F, Paolucci M, Pierucci G, Ragno F, Pellegrino P, Petraglia F, Ciavattini A. Uterine fibroid vascularization: from morphological evidence to clinical implications. Reprod Biomed Online. 2022 Feb;44(2):281-294. doi: 10.1016/j.rbmo.2021.09.005. Epub 2021 Sep 20. PMID 34848152
- BACKGROUNDIdowu BM, Ibitoye BO, Adetiloye VA. Uterine Artery Doppler Velocimetry of Uterine Leiomyomas in Nigerian Women. Rev Bras Ginecol Obstet. 2017 Sep;39(9):464-470. doi: 10.1055/s-0037-1604489. Epub 2017 Aug 7. PMID 28783853
- BACKGROUNDTal R, Segars JH. The role of angiogenic factors in fibroid pathogenesis: potential implications for future therapy. Hum Reprod Update. 2014 Mar-Apr;20(2):194-216. doi: 10.1093/humupd/dmt042. Epub 2013 Sep 29. PMID 24077979