Clinical trial · Observational
Helicobacter Pylori Infection and Gastric Diseases in Lao PDR: First Community-Wide Population-Based Study
A Community-based Collaborative Study for Eradication of Helicobacter Pylori and Associated Gastric Cancer in Luangprabang and Champasak Province, in Lao PDR 2025.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study aims to determine the regional prevalence of Helicobacter pylori infection, bacterial strain differences, and the prevalence of gastric cancer in two provinces of Laos, a multi-ethnic country where these factors may vary by region and ethnicity. The study also evaluates whether H. pylori eradication therapy contributes to disease prevention. Residents aged 18 years or older in Luang Prabang Province and Champasak Province underwent stool antigen testing, and H. pylori-positive individuals received eradication therapy. High-risk participants aged ≥40 years underwent upper gastrointestinal endoscopy for early detection of gastric cancer.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gastric Cancer Screening | — | UNRESOLVED | — |
| Helicobacter Eradication | — | UNRESOLVED | — |
| Helicobacter Infections | — | UNRESOLVED | — |
| Prevention and Control | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- Residents of Luang Prabang Province
- description
- Residents aged ≥18 years in Luang Prabang Province who underwent stool antigen testing for H. pylori. Participants ≥40 years who tested positive additionally underwent upper endoscopy. All positive individuals received triple therapy and were followed for eradication.
- label
- Residents of Champasak Province
- description
- Residents aged ≥18 years in Champasak Province who underwent stool antigen testing for H. pylori. Participants ≥40 years who tested positive additionally underwent upper endoscopy. All positive individuals received triple therapy and were followed for eradication.
Primary outcomes (1)
- measure
- Prevalence of H. pylori infection • Method: Stool antigen test • Time Frame: Baseline
- timeFrame
- Baseline
- description
- The proportion of participants who test positive for H. pylori infection using a stool antigen rapid test at baseline. All enrolled residents aged ≥18 years in Luang Prabang Province and Champasak Province undergo stool antigen testing. H. pylori positivity is defined according to the manufacturer's validated cutoff value. This measure provides a population-based estimate of the current H. pylori infection prevalence in two geographically distinct regions of Laos.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age ≥18 years * Resident of Luangprabang or Champasak Province * Able to provide written informed consent Exclusion Criteria: * Severe comorbidities contraindicating screening or treatment * Allergy to medications used in triple therapy * Pregnant or breastfeeding women (if applicable)
References
Publications (0)
Data not yet available