Clinical trial · Observational
Treatment Strategy for Adult Congenital Biliary Dilation
Surgery-Oriented Classification and Treatment Strategy for Adult Congenital Biliary Dilation
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The management of congenital biliary dilations (CBDs), including choledochal cysts, represents one of the most challenging areas in hepatobiliary surgery due to their potential implications for long-term morbidity and malignant transformation. While CBDs have a relatively low incidence in Western populations (1/150,000-1/100,000), the prevalence is notably higher in Asian countries (1/1,000), making it a significant global health concern. Although complete surgical resection remains the standard of care, the optimal extent of resection and reconstruction strategy, particularly for complex disease patterns, continues to be debated. To address these challenges, the current study proposes a novel surgery-oriented classification system for adult CBD based on the analysis of 234 consecutive cases.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Congenital Biliary Dilation | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| hepatectomy、liver transplantation、hepaticojejunostomy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- underwent surgical treatment for CBD between November 2014 and October 2024
- interventionNames
- Procedure: hepatectomy、liver transplantation、hepaticojejunostomy
Primary outcomes (1)
- measure
- The modified Mayo Clinic score for CBD
- timeFrame
- Last follow-up time (assessed up to 10 year)
- description
- Patients were stratified into excellent, good, fair, and poor categories based on established criteria
Secondary outcomes (2)
- measure
- perioperative complications
- timeFrame
- Perioperative period（Within 3 months after surgery）
- description
- graded according to the Clavien-Dindo classification,23 specific complications assessed using the International Study Group of Liver Surgery (ISGLS) criteria, including posthepatectomy liver dysfunction, bile leakage, and pancreatic leakage24-26
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria ： 1. Age: Adults (≥18 years). 2. Study population: Consecutive patients treated at Beijing Tsinghua Changgung Hospital. 3. Time frame: Underwent surgical treatment between November 2014 and October 2024. 4. Condition/Procedure: Underwent surgical treatment for common bile duct (CBD) diseases. 5. Diagnostic confirmation: Presence, location, and extent of CBD dilatation were diagnosed by preoperative imaging/radiology, and confirmed intraoperatively. Exclusion Criteria ： 1.Secondary biliary dilatation due to proximal obstruction, including intrahepatic and/or extrahepatic bile duct dilatation caused by proximal biliary obstruction, such as: 1. benign stricture, 2. malignant stricture, 3. obstructive stones.
References
Publications (0)
Data not yet available