Clinical trial · Interventional
RCT - Efficacy of Intravenous Vitamin C Versus Placebo on Estimated Blood Loss in Total Abdominal Hysterectomy
Efficacy of Intravenous Vitamin C Versus Placebo on Estimated Blood Loss in Total Abdominal Hysterectomy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Intervention Group: Received two 1 gm doses of Vitamin C intravenously (IV). first Dose: At midnight on the day of surgery. Second Dose: Immediately after the surgical incision. Control Group: Received two doses of a normal saline intravenously (IV) at the exact same times. The primary outcome was to compare intraoperative blood loss between patients who received intravenous Vitamin C and those who did not, following an abdominal hysterectomy under general anesthesia. Intraoperative estimated blood loss (EBL) was meticulously quantified by weighing surgical gauze and measuring suction canister volumes. The secondary outcomes were to evaluate the potential benefits of Vitamin C administration, including: * Reduction in the decline of hematocrit levels after surgery. * Reduction of the length of hospital stay
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Adenomyosis of Uterus | — | UNRESOLVED | — |
| Myoma;Uterus | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Vitamin C (Ascorbic Acid) | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Experimental: Vitamin C
- description
- Intervention Group: Received two 1 gm doses of Vitamin C intravenously (IV). first Dose: At midnight on the day of surgery. Second Dose: Immediately after the surgical incision. Control Group: Received two doses of a normal saline intravenously (IV) at the exact same times.
- interventionNames
- Dietary Supplement: Vitamin C (Ascorbic Acid)
- type
- EXPERIMENTAL
- label
- Placebo
- interventionNames
- Dietary Supplement: Vitamin C (Ascorbic Acid)
Primary outcomes (1)
- measure
- Intraoperative estimate blood loss
- timeFrame
- intraoperative
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 20 Years
Show eligibility criteria text
Inclusion Criteria: * Female patients who underwent total abdominal hysterectomy * No bleeding tendency. * No history of anticoagulant or thrombolytic drug use * No contraindications to vitamin C supplementation Exclusion Criteria: * Inability to communicate in the Thai language. * Underwent total abdominal hysterectomy due to gynecologic malignancy. * Required emergency total abdominal hysterectomy. * History of vitamin C supplementation within 2 weeks prior to surgery. * History of smoking. * Previous abdominal surgery, such as bowel surgery, cesarean section
References
Publications (0)
Data not yet available