Clinical trial · Observational
Optic Nerve Ultrasound for Assessing Cerebral Inflammation and Intracranial Hypertension in Cerebral Pathologies
Utility of Optic Nerve Ultrasonography in Assessing Cerebral Inflammation and Intracranial Hypertension in Patients With Cerebral Impairment
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Timely detection of signs of raised intracranial pressure or persistent inflammation within the meninges can expedite therapeutic decisions improving the prognosis of patients with brain damage. Optic nerve ultrasonography provides a user-friendly, safe, low-cost, and non-invasive imaging method that can be easily deployed for ICU patient assessment. This study aims to evaluate the sensitivity and specificity of optic nerve ultrasound in estimating cerebral inflammation extension and cerebral edema in patients in the ICU. The working hypothesis is that optic nerve ultrasound is a useful tool in the rapid diagnosis of cerebral edema and the presence or persistence of cerebral inflammation, which can enable adapted and rapid therapeutic interventions.
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cerebral Tumors | Cerebral Neoplasm | ALIAS | 0.90 |
| Intracranial Hypertension | — | UNRESOLVED | — |
| Meningitis | — | UNRESOLVED | — |
| Meningitis/Encephalitis | — | UNRESOLVED | — |
| Stroke | — | UNRESOLVED | — |
| Ultrasound | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Optic Nerve Sheath Diameter | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Infectious Pathology Group
- description
- Patients admitted into the hospital with suspected meningitis or encephalitis
- interventionNames
- Diagnostic Test: Optic Nerve Sheath Diameter
- label
- Non-Infectious Pathology Group
- description
- Patients admitted into the hospital with suspected stroke or cerebral tumors (non-infectious pathology)
- interventionNames
- Diagnostic Test: Optic Nerve Sheath Diameter
Primary outcomes (1)
- measure
- Optic Nerve Sheath Diameter
- timeFrame
- Daily during the first week of hospitalisation
- description
- The diameter of the optic nerve sheath measured ultrasonographically using a standardised method, 6mm from the surface of the retina
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 60 Years
Show eligibility criteria text
Inclusion Criteria: * Patients admitted into one of the specified wards of the involved hospitals * Patients aged 18-60 years * Suspected meningitis, encephalitis, stroke or cerebral tumors Exclusion Criteria: * Age under 18 years or over 60 years old * Ocular lesions preventing ocular ultrasound (palpebral infections, cornean erosions, glaucoma, trauma) * Conditions preventing lumbar puncture (coagulation disorders, epidural abscesses, local infections)
References
Publications (0)
Data not yet available