Clinical trial · Interventional
Optimizing Recovery in Pediatric ALL Survivors: A Training Comparison
Optimizing Post-Chemotherapy Recovery: A Head-to-Head Trial of Graded vs. Constant-Load Aerobic Exercise in Pediatric ALL Survivors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study compared the effects of constant-load aerobic exercise (CL-AEx) and graded aerobic exercise (G-AEx) on cardiopulmonary fitness and functional capacity in pediatric survivors of acute lymphoblastic leukemia (ALL). A cohort of 72 pediatric ALL survivors was randomly assigned to one of three groups: a CL-AEx group (n=24), a G-AEx group (n=24), or a control group (n=24). All groups participated in a structured exercise regimen. The CL-AEx group performed additional moderate-intensity aerobic training at a fixed load, while the G-AEx group performed additional aerobic training with progressive increases in intensity and duration. The control group performed the structured exercise regimen only. Interventions were administered three times per week for 12 consecutive weeks. Cardiopulmonary fitness and functional capacity were assessed in all three groups at baseline and following the completion of the 12-week intervention.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Acute Lymphobkastic Leukemia | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Constant-load Aerobic Exercise | Other | — | UNRESOLVED |
| Graded Aerobic exercise | Other | — | UNRESOLVED |
| Structured Exercise regemin | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- CL-AEx group
- description
- The CL-AEx group received a 12-week constant-load aerobic training besides a structured exercise program.
- interventionNames
- Other: Constant-load Aerobic Exercise
- type
- EXPERIMENTAL
- label
- G-AEx group
- description
- The G-AEx group received a 12-week intensity- and duration-graded aerobic training in addition to a structured exercise program.
- interventionNames
- Other: Graded Aerobic exercise
- type
- ACTIVE_COMPARATOR
- label
- Control group
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 10 Years
- Maximum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age between 10 and 18 years old * Complete maintenance chemotherapy * Normal cardiac structure and function * Absence of lower limb deformities * Not engaging in regular exercise regimens Exclusion Criteria: * Secondary cancers * Neurodegenerative impairments affecting memory, attention, or executive functioning * Neuro-musculoskeletal conditions are likely to impede the training.
References
Publications (0)
Data not yet available