Clinical trial · Observational

Quality of Life and Functional Outcomes in Laryngeal Cancer Patients

Assessment of Quality of Life, Patient Satisfaction, Swallowing Function, Voice Outcomes, Pain, and Anxiety-Depression at Baseline and at 3-, 6-, and 12-Month Follow-Up in Patients Diagnosed With Laryngeal Squamous Cell Carcinoma: A Prospective Questionnaire-Based Study

NCT07320820CI-TRIAL-00109099QoL in LSSCnot yet recruitingClinicalTrials.gov clinicaltrialsPublishedExplore in graph →

Summary

Brief summary (as posted)

Laryngeal squamous cell carcinomas are head and neck malignancies that directly affect both swallowing and voice functions and are associated with a significant deterioration in patients' quality of life throughout the treatment process. The aim of this study is to evaluate quality of life, voice and swallowing functions, pain, anxiety-depression levels, and patient satisfaction at the pre-treatment period and at the 3rd, 6th, and 12th months post-treatment in patients with laryngeal malignancies, using validated questionnaires, in order to: Elucidate the course of functional recovery following treatment, Individualize rehabilitation and follow-up strategies, and Examine the relationship between functional outcomes and oncological survival.

Conditions

Conditions (7)

Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.

Condition (as posted)	Mapped entity	Match	Confidence
Anxiety Depression	—	UNRESOLVED	—
Laryngeal Carcinoma	Laryngeal Carcinoma	ONTOLOGY_EXACT	0.98
Pain Management	—	UNRESOLVED	—
Patient Satisfaction	—	UNRESOLVED	—
Quality of Life (QOL)	—	UNRESOLVED	—
Swallowing Function	—	UNRESOLVED	—
Voice Quality	—	UNRESOLVED	—

Interventions

Interventions (6)

Intervention	Type	Mapped drug	Match
Anxiety and Depression Assessment	Other	—	UNRESOLVED
Pain Assessment	Other	—	UNRESOLVED
Patient Satisfaction Assessment	Other	—	UNRESOLVED
Quality of Life Assessment	Other	—	UNRESOLVED
Swallowing Function Assessment	Other	—	UNRESOLVED
Voice Assessment	Other	—	UNRESOLVED

Design

Arms and outcomes

Arms (3)

label
Surgical Treatment Group
description
This group includes patients with laryngeal squamous cell carcinoma who undergo primary surgical treatment, such as partial or total laryngectomy, with or without neck dissection, in accordance with standard oncological indications. Patients in this group may receive adjuvant radiotherapy or chemoradiotherapy when clinically indicated based on pathological findings.
interventionNames
1. Other: Quality of Life Assessment
2. Other: Patient Satisfaction Assessment
3. Other: Swallowing Function Assessment
4. Other: Voice Assessment
5. Other: Pain Assessment
6. Other: Anxiety and Depression Assessment
label
Radiotherapy Group
description
This group consists of patients with laryngeal squamous cell carcinoma treated with definitive radiotherapy as the primary treatment modality. Radiotherapy is delivered according to established clinical protocols, and no surgical intervention to the primary tumor is performed as the initial treatment.
interventionNames
1. Other: Quality of Life Assessment
2. Other: Patient Satisfaction Assessment

Eligibility

Eligibility (as posted)

Sex: All
Minimum age: 18 Years

Show eligibility criteria text

Inclusion Criteria:

* Age ≥ 18 years at the time of enrollment.
* Histopathologically confirmed diagnosis of laryngeal squamous cell carcinoma.
* Planned to undergo surgical treatment or radiotherapy/chemoradiotherapy as part of standard oncological care.
* Willing and able to participate in the study and to provide written informed consent.
* No history of psychiatric or neurological disorders that could impair comprehension, questionnaire completion, or study participation.

Exclusion Criteria:

* Age \< 18 years.
* Presence of comorbid conditions that may independently affect swallowing or voice functions.
* Patients who withdraw consent or request to discontinue participation during or after the treatment period.
* History of psychiatric disorders or use of psychiatric medications that may interfere with study participation or completion of patient-reported outcome measures.

References

Publications (0)

Data not yet available

No reference posted for this study.