A Phase Ib Study of HW211026 Ointment in Patients With Actinic Keratosis.

Key Inclusion Criteria:

* Confirmed as actinic keratosis by histopathology, with Olsen grade 1 or 2.
* A 100 cm² treatment field can be demarcated on the face, which covers clinically typical actinic keratosis lesions (excluding lesions on the lips, perioral region, eyelids, periorbital area, inside and around the nostrils, and the inner ear canal).
* Willing to avoid direct exposure of the treatment field to sunlight or ultraviolet (UV) radiation during the study.

Key Exclusion Criteria:

* Subjects with any of the following conditions within the treatment field：

  * Presence of clinically atypical and/or rapidly changing actinic keratosis lesions, such as hypertrophic lesions, hyperkeratotic lesions, and/or cutaneous horns;
  * Maximum diameter of a single lesion \> 2 cm；
  * History of invasive squamous cell carcinoma, Bowen's disease, basal cell carcinoma, or other malignant tumors；
  * Presence of other skin diseases or conditions that may cause difficulties in examination or evaluation.
* treatment field falls within any of the following locations:

  * Presence of incompletely healed wounds within a 5 cm radius of the treatment field;
  * Presence of suspected squamous cell carcinoma, basal cell carcinoma, or other tumors within a 5 cm radius of the treatment field.
* Subjects with other skin diseases (e.g., atopic dermatitis, psoriasis, eczema, etc.) or other skin conditions (e.g., tattoos, birthmarks, ulcerations, scars, open wounds, etc.) that the investigator deems may interfere with the assessment of safety or efficacy.
* Subjects with severe cardiovascular and cerebrovascular diseases.
* Receipt of any systemic drug therapy for actinic keratosis within 6 months prior to screening.
* Receipt of any topical intervention for actinic keratosis on the administration area within 3 months prior to screening.